A polymer of fluorine-containing sulfonated poly(arylene ether)s and a manufacturing method thereof are provided. The polymer is formed by processing a nucleophilic polycondensation between a fluorine-containing monomer having an eletron-withdrawing group and a multi-phenyl monomer. A main structure of the polymer of fluorine-containing sulfonated poly(arylene ether)s has a first portion with fluoro or trifluoromethyl substituted phenyl groups, and a second portion with sulfonated phenyl groups.

Copolymers of PEEK and PEEK/PEK and methods of preparation thereof are provided. The melt temperatures of the PEEK copolymer and PEEK/PEK copolymer compositions are in the range of 350 C. to 420 C. The compositions are based on PEEK monomers biphenol and 4,4-difluorobenzophenone with other PEEK co-monomers such as hydroquinone and PEK co-monomers such as 4-chloro-4-hydroxybenzophenone, 4,4-difluorobenzophenone and 4,4-dihydroxybenzophenone.

Water vapor transport membranes for ERV and other water vapor transport applications are provided. The membranes include a substrate and an air impermeable selective layer coated on the substrate, the selective layer including a cellulose derivative and a sulfonated polyaryletherketone. In some embodiments the sulfonated polyaryletherketone is in a cation form and/or the selective layer includes s PEEK and CA in an s PEEK:CA (wt.:wt.) ratio in the range of about 7:3 to 2:3. Methods for making such membranes are provided. The methods include applying a coating solution/dispersion to a substrate and allowing the coating solution/dispersion to dry to form an air impermeable selective layer on the substrate, the coating solution/dispersion including a cellulose derivative and a sulfonated polyarylether ketone. In some embodiments the sulfonated polyaryletherketone is in a cation form and/or the coating solution/dispersion includes s PEEK and CA in an sPEEK:CA (wt.:wt.) ratio in the range of about 7:3 to 2:3.

The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.

A polymer of fluorine-containing sulfonated poly(arylene ether)s and a manufacturing method thereof are provided. The polymer is formed by processing a nucleophilic polycondensation between a fluorine-containing monomer having an electron-withdrawing group and a multi-phenyl monomer. A main structure of the polymer of fluorine-containing sulfonated poly(arylene ether)s has a first portion with fluoro or trifluoromethyl substituted phenyl groups, and a second portion with sulfonated phenyl groups.

The present invention relates to the field of drug carrier systems and polymer therapeutics and diagnostics. It provides derivatized unimolecular polyols with a hydrophobic core moiety and a polyanionic, preferably, sulfated hydrophilic shell, N in particular to unimolecular hyperbranched sulfated polyglycerol micelles having a hydrophilic shell and a hydophrobic core. These may be used for the supramolecular encapsulation and transport of hydrophobic guest molecules into biological systems. The micelles can be applied as a drug carrier system for therapy and for diagnosis. They may also be therapeutic agents on their own. The invention also relates to preparation of said micelles.

A non crosslinked, covalently crosslinked and/or ionically crosslinked polymer, having repeating units of the general formula (1)

KR(1)

In which K is a bond, oxygen, sulfur,

##STR00001##

the radical R is a divalent radical of an aromatic or heteroaromatic compound.

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.