A preparation method of a hemostatic material is provided, wherein the method mainly includes mixing a keratin and an alginate; obtaining a keratin-alginate composite scaffold by a freeze-gelation method; and drying the keratin-alginate composite scaffold to obtain a hemostatic material. Further, a methylene blue can be loaded into the hemostatic material so that the hemostatic material has antimicrobial photodynamic abilities.

A preparation method of a hemostatic material is provided, wherein the method mainly includes mixing a keratin and an alginate; obtaining a keratin-alginate composite scaffold by a freeze-gelation method; and drying the keratin-alginate composite scaffold to obtain a hemostatic material. Further, a methylene blue can be loaded into the hemostatic material so that the hemostatic material has antimicrobial photodynamic abilities.

A composition includes a cartilage component for regeneration of cartilage and a manufacturing method therefor. A composition for regeneration of cartilage, in which a micronized cartilage powder is physically mixed with a biocompatible polymer or a chemically crosslinked biocompatible polymer. When applied, the composition can increase morphological retention and ease of use at cartilage injury sites.

A composition includes a cartilage component for regeneration of cartilage and a manufacturing method therefor. A composition for regeneration of cartilage, in which a micronized cartilage powder is physically mixed with a biocompatible polymer or a chemically crosslinked biocompatible polymer. When applied, the composition can increase morphological retention and ease of use at cartilage injury sites.

Disclosed herein is a composite scaffold material that includes a crosslinked polymer matrix formed from a non-mammalian collagen and a crosslinking agent and/or a crosslinked polymer matrix formed from a non-mammalian collagen that has undergone self-crosslinking, and a plurality of calcium phosphate particles distributed within the crosslinked polymer matrix, where the composite scaffold material is porous. Also disclosed herein are methods of manufacturing the composite scaffold material and uses thereof. Further disclosed herein is a method of obtaining collagen from a non-mammalian source.

A medical implant for cartilage and/or bone repair at an articulating surface of a joint is provided. The implant includes a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the articulating and bone contact surfaces face mutually opposite directions and the bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that is formed of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that is formed of a material having chondrointegration properties.

A medical implant for cartilage and/or bone repair at an articulating surface of a joint is provided. The implant includes a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the articulating and bone contact surfaces face mutually opposite directions and the bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that is formed of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that is formed of a material having chondrointegration properties.

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

The present disclosure relates to a method of forming a keratin filament network, comprising: (i) dialysing a solubilized keratin solution in a dialysis buffer solution at a pH of about 2.5 to about 5.5 to obtain purified keratin; (ii) mixing the purified keratin with a salt in the acidic buffer solution; and (ill) drying the solution of step (ii) to form the keratin filament network. In one embodiment, he dialysis buffer solution comprises a weak acid, a denaturing agent and a reducing agent. The said method comprises self-assembly of the keratin filament network. The present disclosure also relates to a keratin filament network comprising at least 2 Type I human hair keratins and at least 2 Type II human hair keratins.