The present application relates to compositions and methods of making flexible composite materials that are capable of moving, on a micro- or macro-scale, in response to an applied magnetic field and localized heat from a heat source. The present disclosure further provides systems and methods of using the flexible composite material as an actuator for performing a mode of actuation. In one embodiment, the flexible composite material forms a wireless actuator that, when irradiated with light, is capable of micro- and macro-scale motion acting through the interplay of optically absorptive elements and low-Curie temperature magnetic particles.

The present application relates to compositions and methods of making flexible composite materials that are capable of moving, on a micro- or macro-scale, in response to an applied magnetic field and localized heat from a heat source. The present disclosure further provides systems and methods of using the flexible composite material as an actuator for performing a mode of actuation. In one embodiment, the flexible composite material forms a wireless actuator that, when irradiated with light, is capable of micro- and macro-scale motion acting through the interplay of optically absorptive elements and low-Curie temperature magnetic particles.

A hemostatic composition of matter includes a coherent blend of collagen fibrils combined with starch particles as a fluffy mass with hemostatic properties better than collagen fibrils alone or starch particles alone, the composition exhibiting a level of coherence wherein the composition can be lifted, without crushing fibrils, without loss of more than 5% of 10% of a total weight of starch particles from the composition. Sheets with less than 10% by weight of additional binder are also disclosed.

The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.

The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.

The present invention relates to a medical implant for cartilage and/or bone repair at an articulating surface of a joint. The implant comprises a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the said articulating and bone contact surfaces face mutually opposite directions and said bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that consists of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that substantially consists of a material having chondrointegration properties.

The present invention relates to a medical implant for cartilage and/or bone repair at an articulating surface of a joint. The implant comprises a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the said articulating and bone contact surfaces face mutually opposite directions and said bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that consists of titanium nitride (TiN) as the wear-resistant material. The cartilage contact surface has a coating that substantially consists of a material having chondrointegration properties.

The present invention provides an enhanced osteogenic composition comprising of connective tissue proteins having molecular weights greater than or equal to 3.5 kDa wherein the composition is prepared by treating demineralized bone material in an acidic extraction medium at a pH between about 0.10 to 0.45 at an extraction temperature between greater than 25 C. and less than 80 C. for a predetermined time period. The present invention further provides a method of making the enhanced osteogenic composition.

The present invention provides an enhanced osteogenic composition comprising of connective tissue proteins having molecular weights greater than or equal to 3.5 kDa wherein the composition is prepared by treating demineralized bone material in an acidic extraction medium at a pH between about 0.10 to 0.45 at an extraction temperature between greater than 25 C. and less than 80 C. for a predetermined time period. The present invention further provides a method of making the enhanced osteogenic composition.

A neutral salt consisting of a polyaminosaccharide cation and an anion, as well as a procedure for the preparation of the neutral salt and uses thereof as a biomaterial and as an ingredient in pharmaceutical compositions are disclosed. Indeed, said neutral salt has surprisingly exhibited high water-solubility and high purity, the preparation procedure having minimised the content of high-risk contaminants in the final product and reduced reaction and purification times.