Provided is an assembled bioreactor chamber comprising an upper end portion, at least one intermediate portion and a lower end portion for forming a chamber of the reactor chamber. The upper end portion and the lower end portion are respectively provided with an interface connected with a culture medium line, and the upper end portion and the intermediate portion, and the intermediate portion and the lower end portion are detachably connected in a sealed manner through a connecting mechanism; when the number of the intermediate portions is ≥2, the adjacent intermediate portions are detachably connected in a sealed manner through a connecting mechanism; and the chamber also comprises a cell carrier for cell attachment growth.

A tool for fixating and handling membrane-shaped tissue for research or clinical use includes a platform having a base plate with at least one positioning element for positioning a spanning element on the platform, at least one round shaped spanning element adapted for being positioned on the platform using the positioning element, at least one flexible element for positioning over the round shaped spanning element for spanning the membrane shaped tissue, and at least one handling means for handling the flexible element during positioning of the flexible element over the round shaped spanning element, and for handling the combination of the round shaped spanning element and the flexible element, when the membrane is spanned over the round shaped spanning element.

A microplate assembly for a plurality of samples includes a donor microplate having a plurality of sample donor cavities. The microplate assembly further includes a receiver microplate having a plurality of sample receiver cavities each sample receiver cavity having a transparent receiver bottom configured to enable microscopic imaging. In addition, the microplate assembly includes a leak-tight connecting structure configured to assemble the donor microplate and the receiver microplate, with at least one of the sample donor cavities being in communication with at least one of the sample receiver cavities. Further aspects are a receiver microplate and a leak-tight connecting structure for a microplate assembly as well as a method for transferring samples by means of a microplate assembly.

Material processing apparatus, systems, methods, and products are described. An example of a material processing apparatus includes a holding member, a base, a tensioning member, an actuator, and a first inner member. The holding member defines a holding member passageway. The base is attached to the holding member. The tensioning member is partially disposed within the holding member passageway. The tensioning member defines a tensioning member passageway. The tensioning member is moveable relative to the holding member between a first position and a second position. The actuator is attached to the tensioning member and is moveable in a first direction and a second direction. Movement of the actuator results in movement of the tensioning member between its first position and second position. The first inner member is adapted to be disposed within the tensioning member passageway.

A concentration device for concentrating a liquid containing a target object, the concentration device including: a container configured to store the liquid containing the target object; a filter in the container; and a position control portion configured to change a position of the filter in the container.

A cell culturing container including a fixed bed is provided for forming a bioreactor (100). In one version, a container in the form of a tubular body is formed by first and second interlocking portions (115a, 115b). The container forms a compartment for receiving the fixed bed (122) for culturing cells, which container may be removably inserted into an inner compartment of the bioreactor so as form an outer chamber for circulating fluid to or from the fixed bed. The container may also include a removable base (130) for receiving an agitator (118) for agitating and thus circulating the fluid. Related methods are also disclosed.

Provided herein are injection molded perfusion-enabled bioreactors and systems including said bioreactors. The bioreactor can include a lid, a frame comprising an an-ay of sample wells, a membrane adhered to a bottom of the frame beneath the array of sample wells, and a skirt adhered to a bottom of the frame, such that the membrane is located between the frame and the skirt. The skirt can include a plurality of channels corresponding to the sample wells. When the sample wells are filled with a 3D cell culture support matrix, a pressure above the 3D cell culture support matrix is atmospheric pressure and a pressure below the membrane is less than atmospheric, thereby perfusing a fluid along a vertical fluid flow path from the sample wells through the

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.

An insect culture maintenance system includes a sequence of open-ended cylindrical tubes [500, 502, 504, 506] joined pairwise alternately at their tops and bottoms using multiple dual-cap connectors. Each dual-capped connector has a channel from an inside of a first cap to an inside of a second cap. In use, connectors that cap the bottoms of the tubes [508, 512] are filled with insect food media [518, 520], while connectors that cap the tops of the tubes [510] are open. As a result of this design, adults pass from one tube to the next through the top dual-cap connectors, while larvae pass from one tube to the next through the bottom dual-cap connectors, resulting in propagation of subsequent generations of insects through the sequence of tubes.