A sensor positioning system for a bioprocess engineering unit, wherein a container is provided for receiving a biological medium which, when installed, extends in the axial direction from an upper container end to a lower container end, wherein a holder is provided for holding the container when installed, wherein a sensor is provided for fixing to the container. A positioning aid device for positioning the sensor to be fixed is provided on the container, the positioning aid device has a positioning aid that can be applied directly to or near the container on the holder, which can be brought into different vertical positions and/or circumferential positions relative to at least one reference point provided on the container and/or holder, and the positioning aid device has a technical storage medium or analog print medium with an allocation list.

An intravaginal culture device includes an outer housing configured for vaginal insertion. The outer housing includes an upper portion that removably couples with a lower portion. A first inner vessel is located at the upper portion and is configured to house a first plurality of embryos. A second inner vessel is located at the lower portion and is configured to house a second plurality of embryos.

A component management apparatus for a bioprocessing system includes a frame having a plurality of segments, including at least a first segment and a second segment pivotably connected to the first segment such that at least the second segment is movable between a closed position and an open position, and at least one mounting bracket connected to the frame for connection of a bioprocess component.

A device for measuring a tension of a cell structure containing muscle cells includes a first and a second gel adaptor holder. The first gel adaptor holder includes a frame member and a first gel holding portion which is disposed protrudingly from a part of an inner surface of the frame member for fixing one end of a gel. The second gel adaptor holder includes a second gel holding portion that fixes another end of the gel, and connecting members connected with the second gel holding portion. A kit including the device, a substrate and a gel forming cover. The substrate includes a pair of gel shaping convex parts fitted along the inner surface of the frame member. The gel forming cover includes a surface parallel to a gel contacting surface of the substrate, in order to form an upper surface of the gel.

Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.

A reactor module includes a lower body, an upper body, a top cover and a culture vessel. The lower body defines and surrounds a bottom space that has an upper opening. The upper body is detachably connected atop the lower body. The top cover is disposed atop the upper body, and cooperatives with the upper body to define a receiving space that is disposed above the bottom space. The culture vessel is removably received in the receiving space, defines a culture reservoir, and includes a film member that is disposed under the culture reservoir, and that blocks the upper opening of the bottom space.

Differential pressure material processing systems, apparatus, methods, and products are described. An example embodiment of a differential pressure material processing system includes a tank, a holding member, and a sheet of tissue disposed within the holding member. The holding member defines a first holding member chamber and a second holding member chamber. The first holding member chamber has a first pressure when a fluid is disposed within the first holding member chamber. The second holding member chamber has a second pressure when a fluid is disposed within the second holding member chamber. The second pressure is different than the first pressure.

A container system includes a flexible bag, a probe port, and a probe. The probe port includes an elongated tubular member having an interior surface bounding a first passageway extending between a first end and an opposing second end, the tubular member being made of a polymeric or elastomeric material and being flexible. The probe port also includes a flange coupled to the tubular member and radially outwardly projecting therefrom, the flange being secured to the flexible bag so that the first end of the tubular member projects into a chamber of the flexible bag while the second end of the first passageway of the tubular member is accessible from outside of the flexible bag. The probe can be received within the first passageway of the probe port.

Devices and methods for culturing microorganisms are disclosed. In some aspects, the devices include two frame bodies. The two frame bodies may comprise a first-type frame body and a second-type frame body. The first-type frame body may comprise a first frame body surrounding a first internal space. The first frame body may comprise an inflow passage for a fluid to flow into the first internal space and an outflow passage for the fluid to flow out from the first internal space, the inflow passage and the outflow passage being each provided to be openable and closable. The second-type frame body may comprise a second frame body surrounding a second internal space. In some aspects, the two frame bodies are stackable on each other.

A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.