The present disclosure provides a delivery consumable for delivering a fluid to a bioreactor. The delivery consumable comprises a container including a collapsible portion comprising a collapsible wall, and an intermediate portion connected to the collapsible portion and being adapted to hold a fluid. The deliver consumable also comprises a connector adapted to connect the intermediate portion to the bioreactor. The collapsible portion is adapted to collapse and urge the fluid through the connector and into the bioreactor.

An assembly for handling biological material, including a planar interface having at least one port, and a component retaining element, spaced apart from the planar interface, configured to retain a component for handling biological material, in which at least one component chosen from the planar interface and the component retaining element is moveable to bring the port and the component retaining element into registration with one another. The registration between the at least one port and the component retaining element adapted to form a fluid communication pathway may be provided between a component retained by the component retaining element and a container associated with the planar interface through the port.

The invention relates to an installation for biotechnological applications (1, 101), comprising an improved holder system (4) with at least one carrier (10) for the mounting of components (5) of the installation (1, 101) on the installation (1, 101). The carrier (10), which comprises a frame (12) with two arms (14) and with a recess (16) and includes a deformable element (30) with at least two fastening sections (32), which may be understood to have a flat base (20) by which the carrier (10) can be fastened to the installation (1, 101). The deformable element (30) is designed to assume the following states: a receiving state AUZ, in which the deformable element (30) is available for receiving a component (5) of the installation (1, 101); and a locking state ARZ.

An insect culture maintenance system includes a sequence of open-ended cylindrical tubes [500, 502, 504, 506] joined pairwise alternately at their tops and bottoms using multiple dual-cap connectors. Each dual-capped connector has a channel from an inside of a first cap to an inside of a second cap. In use, connectors that cap the bottoms of the tubes [508, 512] are filled with insect food media [518, 520], while connectors that cap the tops of the tubes [510] are open. As a result of this design, adults pass from one tube to the next through the top dual-cap connectors, while larvae pass from one tube to the next through the bottom dual-cap connectors, resulting in propagation of subsequent generations of insects through the sequence of tubes.

Disclosed herein are details of a hermetically or aseptically sealed bioreactor. The bioreactor comprises a bioreactor chamber, a membrane wall, a scaffold structure, a linear actuator, a linear transfer means, and a control system. Use of the bioreactor permits the inner scaffold structure to be moved and manipulated while still preserving a hermetic or aseptic seal inside the bioreactor chamber during operation.

The presently disclosed subject matter provides devices, systems, and methods for model inter-organ communication. In some embodiments, a multi-organ-on-a-chip (MOC) system can include one or more micro-culture well configured to receive a live tissue sample therein and an impeller-based pump in fluid communication with the one or more micro-culture well. In this arrangement, the impeller-based pump can be configured to generate fluid flow through the one or more micro-culture well.

A filtration assembly is provided, comprising a reservoir for holding a sample to be filtered, the reservoir having open top and bottom ends, and inwardly facing arms arranged at the bottom end, the reservoir having an elastic side wall; a fluid port in fluid communication with the reservoir; a porous microorganism-capturing filter element disposed across a flow path between the reservoir and the port, the filter element being releasably retained by the inwardly facing arms; an absorbent pad arranged below the filtration element and the inwardly facing arms, disposed across the flow path between the reservoir and the port; a base detachably mounted to the reservoir, the base including the port, and a support surface for supporting the pad; wherein compressing the elastic side wall releases the filter element from the inwardly facing arms after the base is detached from the reservoir.

A horizontal flow bioreactor facilitates continuous flow conditions to cells grown on a tissue engineered scaffold. More particularly, interstitial fluid flow conditions are mimicked around cells inside the body, thereby improving the mass transfer rates of cells and providing physical stimulus to the cells. Unlike the available perfusion based vertical bioreactors where flow is vertical through scaffolds, the horizontal flow reactor enables studies on attachment of cells to substrates, tissues, and bone mimetic scaffolds. The horizontal bioreactor further aides study of cell proliferation, cell migration, cell clustering, biology of cell growth, cell response, cell filtration techniques for capturing tumor cells, the testing of drugs, and drug delivery under flow conditions. The horizontal bioreactor can mimic in vivo conditions, epithelial to mesenchymal transition (EMT), and mesenchymal to epithelial transition (MET).

A bioreactor including a containment structure containing a liquid culture medium for cultivating seaweed. The containment structure includes a sidewall extending vertically between a top and bottom section where the bottom section has an effluent arranged to allow extraction of cultivated seaweed. A spiral liner is positioned adjacent to an inside surface of the sidewall. The recirculator includes a pump arranged to continuously receive a portion of the liquid culture medium via an inlet from the bottom section and output the liquid culture medium via the outlet at the top section. Sensors monitor environmental conditions within the bioreactor. Light emitters are arranged along a surface of the spiral liner. Flow generators, positioned within the containment structure in a spiral configuration between the top section and bottom section, are configured to direct a flow of the liquid culture medium from the top section toward the bottom section of the containment structure.

A device for cultivating tissue sections, in particular for testing active ingredients and/or medications, includes a frame, at least one carrier component designed to hold a tissue section, and at least one liquid-absorbing strip element. The frame is designed to hold the at least one carrier component and the at least one strip element. A cultivation system includes the device for cultivating tissue sections and a holding vessel. The device can be used for testing active ingredients or medications on a tissue (section).