Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.

The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).

A microscope for microscopic examination of a sample includes an illumination optics for illuminating the sample, an imaging optics for imaging the sample, a sample chamber for receiving the sample. The sample chamber has a door providing access into the sample chamber. The microscope further includes a first fan assembly arranged on a first side of the sample chamber for blowing atmosphere into the sample chamber or for draining atmosphere out of the sample chamber, through at least one first opening arranged on the first side in a first side wall of the sample chamber, and at least one second opening arranged on a second side in a second side wall of the sample chamber for allowing atmosphere from inside the sample chamber to exit the sample chamber or for allowing atmosphere from outside the sample chamber to enter the sample chamber.

This invention relates to compositions of matter, methods, modules and instruments for automated mammalian cell growth and mammalian cell transduction followed by nucleic acid-guided nuclease editing in live mammalian cells.

Provided is a drive mechanism capable of withstanding sterilization treatment using a sterilization gas such as hydrogen peroxide and capable of performing positioning operation with heightened accuracy. In a drive mechanism according to the invention, a movable block disposed in the internal space of a partition wall for blocking a sterilization gas is coupled to a movable platform disposed in the external space of the partition wall by means of a magnet coupling mechanism. Further, biasing magnet units are disposed on surfaces, of the movable block and the movable platform, on which no magnet coupling mechanism is disposed, such that the biasing magnet units serve as magnetic poles repelling each other. Repelling force generated by the biasing magnet units serves as biasing force that biases the movable platform toward the partition wall.

An apparatus for culturing cells of the present disclosure includes: a cabinet that has a main surface and a side surface, the main surface having a window; a main surface aspiration port disposed at the main surface of the cabinet; and a side surface aspiration port disposed at the side surface of the cabinet. In the cross section of the cabinet taken along the horizontal direction, a first vessel supplying part for supplying a first vessel is disposed at a midportion of the cabinet, and a second vessel supplying part for supplying a second vessel is disposed at an inner peripheral portion of the cabinet. The first vessel supplying part has a first lid capable of entirely covering the first vessel supplying part. The first vessel has no lid. The second vessel supplying part has no lid. The second vessel has a second lid.

The present disclosure provides an automated system for processing of tissue. The system comprises a plurality of containers for storing at least one of tissue samples, buffer solutions, enzymes and other reagents, tissue processing container for processing of the tissue, and a robotic assembly coupled to the tissue processing container. The robotic assembly is configured to: carry the tissue processing container towards each of the plurality of containers, and align an inlet port of the tissue processing container with an outlet port of each of the plurality of containers for collecting the liquids, and moves the tissue processing container in multiple-planes to perform at least one of the washing processes, digestion process, phase separation process and combination thereof. The system also comprises of a control unit interfaced with the robotic assembly for controlling operations of the robotic assembly while processing the tissue.

A cell picking device includes a supporter that supports a rack having a plurality of holes for holding a plurality of pipette tips, a sucker used to suck a sample, a driver that moves the sucker in an up-and-down direction and moves the sucker and the supporter relative to each other in a horizontal direction, and a controller that controls the driver such that, any pipette tip out of the plurality of pipette tips held by the rack is attached to the sucker by movement of the sucker in the up-and-down direction and the sucker is moved to a position outwardly of the rack by movement of the sucker and the supporter relative to each other.

A method for printing uses at least one bio-ink. The method also uses at least one laser print head to deposit at least one droplet of at least one bio-ink onto a depositing surface of a receiving substrate. The printing method uses at least one nozzle print head to deposit at least one droplet of at least one bio-ink onto a depositing surface of the same receiving substrate as the laser print head.