The present disclosure provides a power device of a micro channel for external circulation of a bioreactor. The power device of the micro channel may be disposed outside the bioreactor and in fluid connection with the bioreactor, the power device of the micro channel may be of a shape of a box body. The power device of the micro channel may comprise: a stacked layer disposed in the box body, including a first shell plate, a second shell plate, and a sealing film sandwiched between the first shell plate and the second shell plate; and a liquid buffer device including a first liquid cavity and a second liquid cavity disposed in the box body, the first liquid cavity and the second liquid cavity may be fixed to an outer end surface of the stacked layer. The power device of the micro channel may be of a box shape, thereby reducing the volume and production cost thereof.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

A microorganism screening system includes a container configured to store a liquid containing microorganism particles and a liquid medium, and a microorganism separation device. The microorganism separation device includes a hydrodynamic separation device and a liquid feeding unit configured to supply the liquid from the container to the hydrodynamic separation device. The hydrodynamic separation device includes a curved flow channel having a rectangular cross-section, and is configured to separate the liquid into a first segment containing relatively large microorganism particles and a second segment containing relatively small microorganism particles through use of a vortex flow generated in the liquid flowing through the curved flow channel. Screening for microorganisms can be performed efficiently.

An object of the present disclosure is at least to provide a device that can easily introduce a substance into cells in vitro with high efficiency and in a short time, and the object is fulfilled by a device for introducing a substance into cells in vitro, the device comprising: an accommodation unit for accommodating a solution containing cells and a substance; and a driving unit for pressurization of the solution, wherein regarding the pressurization of the solution, time from when the pressurization starts until pressure reaches a maximum pressure is 2.0 msec or shorter.

The invention relates to a bioprocessing system having a main line (2) for conduction of a main flow (3) of a liquid, in particular biological, medium (45), having a main flow pump (5) for generation of the main flow (3) and having a system part (46) connected to the main line (2). What is proposed is that the bioprocessing system (1) comprises a powder transfer system (8) for metered delivery, in particular dust-free metered delivery, of an additive (47) and a feed line (9) which is connected to the powder transfer system (8) and which opens into the main line (2) at a feed point (10) and which comprises a return flow preventer (11) for prevention of a return flow of liquid medium (45), that the powder transfer system (8) feeds the additive (47) into the feed line (9) in powder form and drives it toward the feed point (10) by means of a pressurized transport gas (12) and that at least some of the fed additive (47) is input into the liquid medium (45) within the main line (2) downstream of the feed point (10) before the liquid medium (45) enriched with the additive (47) passes through or reaches the system part (46) connected to the main line (2).

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Disclosed herein are methods, systems, and compositions for the pretreatment of biomass within seconds with low inhibitor formation. The pretreatment process is used to convert biomass to a fuel or other useful chemicals by subjecting the feedstock to a rapid retention time under pressure and temperature and/or chemical reactant. The system includes a continuously-operating valve discharge apparatus to discharge pretreated feedstock while maintaining uniform pressure on the pretreatment system.

Cell culture systems and methods provide improved immunotherapeutic product manufacturing with greater scalability, flexibility, and automation. Cell culture systems are configured with interchangeable cartridges, allowing versatility and scalability. Systems are configured to have multiple connected cell culture chambers, which allows parallel processing of different types of cells. Gas-impermeable cell culture chambers and methods for generating cells in closed systems prevent contamination and user error. Methods for recycling cell culture medium provide additional efficiencies.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

To provide a method of efficiently performing priming on a microparticle sorting microchip.

The present technology provides a priming method of a microparticle sorting microchip provided with a sample liquid flow path, a sheath liquid flow path that joins the sample liquid flow path at a junction, a joined flow path including the junction at one end, a microparticle recovery flow path connected to the joined flow path via a connection flow path at the other end of the joined flow path, a branching flow path connected to the joined flow path at the other end of the joined flow path, and an introduction flow path configured to introduce a liquid into the connection flow path, the method provided with a first priming step of supplying a first liquid from the introduction flow path to the connection flow path, and performing priming on the microparticle recovery flow path by the first liquid, and a second priming step of allowing a second liquid to flow from the sheath liquid flow path to the joined flow path, and performing priming on the branching flow path by the second liquid.