Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Embodiments of the present disclosure relate to a magnetic bead platform for isolating sperm cells from biological samples. In some embodiments, such magnetic bead platforms integrate recognition reagents to its surface to bind target cells, such as sperm cells. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological samples as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.

Method for generating and controlling complex strain patterns on biological materials comprising the steps of providing a magnetic stimulation device and a magneto-responsive substrate; culturing biological material in the substrate; determining the position of the magnetic stimulation device for obtaining a defined strain pattern on the biological material; placing the magnets in the position determined; and activating a magnetic stimulation device to generate a complex strain pattern in the magneto-responsive substrate and consequently in the biological material; and magneto-mechanical stimulation system comprising a magneto-responsive substrate configured to hold biological material; a holder for placing the magneto-responsive substrate; a magnetic stimulation device configured to generate a complex strain pattern on the biological material by generating a magnetic field which acts over the magneto-responsive substrate; a computing module; an imaging module for long-term monitoring; and an interface module for performing the steps of the method.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

The present invention provides a cell culture base that avoids contact between a photoresponsive layer and cells. The cell culture base of the present invention includes: a support layer; a photoresponsive layer; and a cell culture layer, wherein the photoresponsive layer is laminated on the support layer, the cell culture layer is laminated on the photoresponsive layer, the photoresponsive layer contains a photoresponsive substance that causes at least one of heat and change in magnetism by light irradiation, and the cell culture layer is capable of culturing cells.

The presently disclosed subject matter provides devices, systems, and methods for model inter-organ communication. In some embodiments, a multi-organ-on-a-chip (MOC) system can include one or more micro-culture well configured to receive a live tissue sample therein and an impeller-based pump in fluid communication with the one or more micro-culture well. In this arrangement, the impeller-based pump can be configured to generate fluid flow through the one or more micro-culture well.

The present invention relates to a method and an apparatus for in vitro three-dimensional cell co-culture, wherein said method comprises a step of seeding a plurality of cells of a first cell type on a first magnetic prismatic porous scaffold and a plurality of cells of a second cell type on a second magnetic prismatic porous scaffold, while keeping the first and second scaffolds physically separate, and a step of moving the first and second scaffolds towards each other under the action of a magnetic field generated by a magnetic field generator until contact occurs on at least one surface.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.

The disclosure relates to a cell processing unit for cell and gene therapy manufacture comprising a housing defining an enclosure into which a cell processing platform can be mounted, a platform mounting bracket within the housing and configured and arranged to receive and retain a cell processing platform, a drive apparatus configured and arranged to operatively engage and act upon a cell processing platform to move same with respect to the platform mounting bracket, and an actuator configured and arranged to exert a force on a container mounted into the cell processing platform to expel a contents from the container.