Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use. A portable device for use with a module is also provided.

The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. ##STR00001## Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

An apparatus for receiving and processing organic waste by anaerobic bioconversion comprising a closed tank which is the bioconversion site, provided in the top portion thereof with a gasometric bell for storing and pressurizing the biogas produced, around which the external members of the apparatus are distributed on a pod which also forms the support for a body of the digester. The tank, in a preferred embodiment, comprises a main enclosure which is the bioconversion site, and a secondary central enclosure called the crop, intended to receive and store the organic waste to be processed before the dosing of same into the main enclosure to complete the bioconversion. The crop forms a removable subassembly that can be configured in different ways, with a circulation and distribution block on which it is secured and with a liquid-solid phase separator which is mounted over same. This subassembly engages with a mechanical stirrer for stirring the fermentative medium contained inside the tank, driven by the gasometric bell, which is centered and rotated by a drive device, for example one carried by the arm of a telescopic bracket mounted over same, or by a drive ring.

The liquid feeder includes a liquid feeding pipe having a liquid introduce port and a liquid discharge port, a housing container which holds liquid to be introduced from the liquid introduce port, a liquid feed mechanism which feeds the liquid in the liquid feeding pipe to the liquid discharge port, a gas introduce unit which introduces gas into the liquid feeding pipe, and a liquid level detection unit which detects an advancing liquid level of the liquid to be fed in the liquid feeding pipe. The gas introduce unit is connected to a branch part provided in the liquid feeding pipe on the upstream side of the liquid feed mechanism. The liquid level detection unit is provided on the downstream side of the branch part.

A laboratory container, in particular a cell culture container, includes a container volume which is surrounded by a container body and which can be accessed from the outside through a container opening of the container body. The container has a fluid line which communicates with the container volume and which comprises a valve arrangement. The fluid line is designed to conduct fluid in order to discharge and/or introduce fluid out of and/or into the container volume. The fluid line can be selectively released in order to conduct a fluid or blocked by the valve arrangement, and the container additionally has a gas balancing opening, through which gas can be introduced into or discharged out of the container volume in counterflow to a possible fluid flow in the fluid line. The gas compensating opening is surrounded by a channel wall, said line channel running from the gas balancing opening into the container volume and opening into said container volume.

An electrochemical measurement method for electrochemically measuring a chemical substance generated or consumed in a biological sample in a solution is provided which includes performing measurement by placing the biological sample at a distance away from an electrode surface in the direction perpendicular to the electrode surface. The distance is determined in advance on the basis of simulation in which a current flowing through a working electrode.

A method of producing bioethanol in a bioethanol system and a control system for a bioethanol system is disclosed, the control system comprising a controller comprising one or more processors and an interface, wherein the one or more processors are configured to obtain a grain flour flow of grain flour; determine an input scheme based on the grain flour flow; and control one or more input devices of the bioethanol system according to the input scheme. The one or more processors may further be configured to sense one or more indicators associated with a fermentation (e.g., bioethanol) system, to determine a yeast blend ratio based at least partially on the one or more indicators, generate one or more control signals based on the determined yeast blend, and convey the one or more control signals to the fermentation system. Associated systems, apparatuses, and methods are also disclosed.

A bioreactor chamber for growing a cell culture in a liquid medium includes a controller, sensors coupled to the bioreactor chamber, control devices for varying a gas flow and/or a fluid flow in the bioreactor chamber. The plurality of sensors is configured to measure a plurality of sensor parameters in the liquid medium. Sensor data from each of the sensors is received at predefined time intervals. A desired cell growth configuration and the sensor data from each of the sensors are inputted into a cell culture control machine learning model. Performing, based on output data from the cell culture control machine learning model, transmitting a control circuitry command to a control device to control at least one of: a display of a cell culture parameter prediction, a gas flow, a liquid flow of a nutrient fluid, or a removal of waste products from the liquid medium.

Methods and devices for monitoring the content of mixed reactors, where the reactor has at least one property to be monitored that influences at least one signal of at least one sensory component, where the at least one sensory component moves within the reactor so that it is not permanently located in the detection region of the at least one measuring arrangement, and detection is carried out by at least one measuring arrangement while the at least one sensor is located in the detection region.

A state inference system includes: a measurement unit for using any of a culture medium, a culture cultured by using the culture medium, a culture medium extract extracted from the culture medium, and a culture extract extracted from the culture, as a biological sample and a target biological sample, and measuring characteristics of a plurality of biological samples including the biological sample at a certain time point and characteristic of the target biological sample being the same type as the biological sample at the certain time point; a database for storing a feature amount extraction model that characterizes a distribution of input data including at least characteristic values of the plurality of biological samples acquired through the measurement unit; and a state inference unit for inferring a culture state of the culture or inferring a culture time.