The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase.

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Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic acid (CBCA) in different ratios. The apparatus comprises: (i) a bioreactor comprising (a) an automated supply system configured to deliver a first automated supply of cannabigerolic acid (CBGA), a cannabinoid acid synthase, and a reaction mixture; and (b) a second automated system to cease the reaction; (ii) a controller configured to modify a property of the reaction mixture to produce the desired products; and (iii) an extractor configured to recover the tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) or cannabidiolic acid (CBDA) and cannabichromenic acid.

The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase.

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Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

The invention is a method of two-phase anaerobic digestion where monitoring and adjusting the nitrogen status (carbon to nitrogen molar ratio, i.e. C/N molar ratio or total or ammoniacal nitrogen content) enables maintaining optimum conditions during the process. The method improves the use of a variety of feedstock materials or facilitates monodigestion of one feedstock. Especially the introduction of nitrogen rich feedstock materials in the process is amended. A community of hydrolyzing and acidogenic microorganisms in the first phase digester performs ammonification i.e. release of organic nitrogen as ammonia. Nitrogen and phosphorus are removed and recovered from the digestate which then undergoes biogasification in the second phase of the process. Reject water from biogasification can be recycled within the process.

The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase.

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Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.

A microfluidic device, a microfluidic system comprising said microfluidic device, and to a method of culturing biological material.

Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.

The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic acid (CBCA) in different ratios. The apparatus comprises: (i) a bioreactor comprising (a) an automated supply system configured to deliver a first automated supply of cannabigerolic acid (CBGA), a cannabinoid acid synthase, and a reaction mixture; and (b) a second automated system to cease the reaction; (ii) a controller configured to modify a property of the reaction mixture to produce the desired products; and (iii) an extractor configured to recover the tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) or cannabidiolic acid (CBDA) and cannabichromenic acid.

The present invention provides an intracellular radiation microdosimetric detection structure and detection method, and relates to the field of radiation microdosimetric detection technologies. The detection structure includes a first semiconductor detector unit, a first pixel array detector, a cellular microfluidic chip, a second pixel array detector, and a second semiconductor detector unit that are sequentially arranged in layers. The cellular microfluidic chip is configured for cell fixation and culture. The first semiconductor detector unit and the second semiconductor detector unit form a charged particle energy information detector combination for detecting deposit energy of charged particles in a semiconductor detector. The first pixel array detector and the second pixel array detector form a charged particle flux and position information detector combination for measuring a flux and an angle of charged particles incident at a position of the cellular microfluidic chip.

The invention modernizes abandoned or inefficient petrochemical plants for the production of jet fuel, diesel, naphtha, drilling fuels and wax. It utilizes an amine system shifted in a brownfield situation and a PRISM unit to cleanse incoming syngas and obtain an optimal H2:CO ratio for conversion. The refit and repurposing introduces novel heat transfer elements to a Fischer-Tropsch (FT) reactor and embarks a proprietary FT catalyst for the production of GTL products. It also incorporates unique FT analyzers to monitor hydrocarbon streams and aid production and Coriolis flow meters for precise measurements of liquid wax flow, unaffected by wax congestion or vibration. Feedstocks include numerous sources such as Natural gas, Biomass, etc