A stirring apparatus including a stirring mechanism configured to execute a stirring process on cells in a culture vessel, and a control unit programmed to at least one of control the stirring mechanism, determine the stirring process of the stirring mechanism, and determine whether the stirring process is performed or not.

The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network.

A biological cell preservation or culturing arrangement (20) comprises a chamber defining a fluid retaining space (30) for retaining in use a body of fluid (34) and a deformable membrane (36) in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement (38) to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region (46) immediately proximal the deformable membrane and a sub-region (48) removed from the deformable membrane.

The present application provides a reactor with an inclined bottom gas-inlet for aerobic fermentation. A fermenter is provided with a circular inner tank, end covers and a jacket. An airtight fermentation space is formed in the fermenter by the inner tank, an upper end cover and a lower end cover. A feed opening and an exhaust outlet are arranged at an upper part of the fermenter, and a discharge opening is arranged at a lower part of the lower end cover of the fermenter. An energy-saving stirrer is mounted in the fermenter. A plurality of air chambers are arranged at an external wall at the bottom of the inner tank of the fermenter and are within the jacket. A plurality of aeration nozzles are defined on an inner side of each air chamber, and the aeration nozzles are disposed next to the inner tank.

A process for optimizing the operation of a plug-flow fermenter for the anaerobic fermentation of organic wastes, wherein the plug-flow fermenter comprises a horizontally oriented fermenter tank and a stirrer, which stirrer comprises a stirrer shaft which traverses the interior of the fermenter tank in an axial manner and multiple paddles which are arranged on the stirrer shaft and protrude radially and also a drive, and the fermentation material is moved in the fermenter tank by means of the stirrer.

A bioreactor for producing hydrogen gas and metabolites and methods for making and using the same. The bioreactor comprises a main reactor chamber, a semipermeable membrane, a sleeve, microorganism, such as cyanobacteria, for producing hydrogen gas and metabolites, a power supply, a substrate medium, a heating member, a plurality of tubing members, a collection reservoir, a pressure-sealed connecter member, a metabolite purifying filter member, a light source, and an agitator. The bioreactor utilizes light, fermentation, and other metabolic processes for the production of metabolites, derived from various microorganisms contained within the bioreactor through respective metabolic pathways.

A method and a device for adherent culture of microalgae in a thin liquid layer by mobile mechanical stirring, comprising: a subsystem for adherent culture of microalgae in thin liquid layer, for adherent culture of microalgae in a culture solution, comprising a microalgae liquid pool and a culture plate used as a base plate for microalgae seed inoculation, adherent culture, microalgae harvesting, the microalgae liquid pool containing culture solution having a water layer with a depth in a range of 1{tilde over ()}5 cm, forming a thin liquid layer; and a subsystem for mechanical stirring, comprising a mechanical stirring assembly, a moving assembly, a track member, a power drive assembly, a control assembly, the moving assembly moving on the track member to drive the mechanical stirring assembly to stir and suspend the microalgae, the microalgae standing and gradually settling to the bottom after stirring, realizing adherent culture in suspension and settlement cycle.

An incubator system configured to illuminate at least one or more cell culture chamber devices and to rotate them about a respective predetermined axis, each cell culture chamber device comprising an enclosure, the enclosure configured to contain a cell culture media, and at least one viewing area configured to allow inspection of at least a part of the cell culture media, the incubator system further comprising at least one illumination device and at least one monitoring device, the at least one monitoring device configured to provide one or more monitoring signals of at least part of an illuminated cell culture media or an illuminated cell culture chamber, illuminated, by at least one of the at least one illumination device, with a signal of electromagnetic radiation, preferably incoherent or coherent ultraviolet, visible, infrared, and/or near-infrared light of broad or narrow wavelength spectrum, and wherein the incubator system further comprises or is in connection with one or more processing units configured to extract and/or derive data from the one or more monitoring signals, said data representing one or more aspects of the cell culture chamber device itself and/or the cellular activity occurring within.

Systems and methods of testing a fluid sample are provided. A method can include controlling an orientation of a loader including a sample holder configured to hold a sample vessel to correspond to a first predetermined tilt angle. The method can include controlling an articulator to transfer the fluid sample from the sample vessel to at least one well of a plurality of wells of a multiwell plate positioned on a plate deck within the enclosure. The method can include controlling the articulator to move the multiwell plate to a hotel incubator within the enclosure. The method can include applying a bacteriophage to the fluid sample. The method can include controlling the articulator to move the multiwell plate from the hotel incubator to a testing system within the enclosure after a predetermined reaction time period. The method can include receiving output data from the testing system.

The present set of embodiments relate to a system, method, and apparatus controlling a cell culture media mixing system. The control system includes an integrated control unit capable of controlling a broad ranges of peripheral devices commonly used in bioproduction through a graphical user interface displayed on a touch sensitive screen. The bioproduction system is designed to be highly customizable through process modification and recipe creation by user with little or no knowledge of programming and is capable of controlling a wide variety of devices using a single unit. The bioproduction system allows for auto-detection, auto-calibration, and automatic of device related processes into a bioproduction workflow.