Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced.

Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Provided herein are systems, devices and methods to automate and optimize the decellularization process of representative tissues, such as soft tissues, for extracellular matrix (ECM)-based scaffold and biomaterial production. The automated decellularization processes and devices significantly reduce the exposure time to reagents, minimize lot-to-lot variability, and largely preserve the native composition of the ECM from the decellularized tissue or species.

A cell processing system includes a processor connectable to a source container filled with a biological fluid and one or more wash media containers. The processor includes a separator connectable to the source container and a product container, the separator configured to separate the biological fluid from the source container into at least two streams. In addition, a controller is coupled to the processor and configured to: cause the separator to separate the biological fluid into at least two streams, direct one of the at least two streams into the product container, subsequently pause processing of the biological fluid, after pausing, determine a measured cell count in the product container, and add fluid to the product container from the wash media containers as a function of the measured cell count in the product container while the product container is connected to the wash media containers.

A fermenter for biogas plants, including a submersible motor-driven stirrer that can be vertically adjusted by means of a motor. During operation of the biogas plant, the fermenter is filled, to a level, with substrate that is to be fermented, and the agitator blades of the submersible motor-driven stirrer are fully immersed in the substrate. According to the invention, a level gauge is provided, by means of which the level of the substrate is detected and a corresponding level measuring signal is generated as an actual level signal. Furthermore, a control device is provided, to which the level measuring signal is fed and which controls the vertically adjusting motor for the submersible motor-driven stirrer in such a way when a lower level is detected that the stirrer is lowered and the agitator blades continue to be fully immersed in the substrate.

A fluid filtration system includes a fluid storage vessel such as a bioreactor, a filter housing including a filter element disposed therein, a pump coupled between the fluid storage vessel and the filter housing, and a flow diverter disposed between the pump and the filter housing. The pump is configured to move fluid from the fluid storage vessel through the filter element, and the flow diverter is configured for selectively directing fluid received from the pump to the first or second end of the filter housing. In a first mode of operation, the flow diverter directs flow through the filter housing in a first direction, while in a second mode of operation, the flow diverter directs flow through the filter housing in a second direction opposite the first direction.

The present disclosure provides a bioreactor for cell processing. The bioreactor comprises a container including a base section comprising a sensor window chosen from a transparent sensor window or a translucent sensor window, a top section arranged opposite to the base section and comprising a fluid inlet and a fluid outlet, and a sidewall extending between the base section and the top section and defining an internal volume of the container adapted to hold a cell suspension. At least one optical element disposed on the sensor window within the internal volume, the at least one optical element adapted to emit a fluorescence signal in response to incident light, the fluorescence signal associated with one or more parameters of the cell suspension.

A system and a method for monitoring and regulating the level of contents in a vessel is disclosed. In some embodiments, the system or the method use laser beams and photosensors to determine the level of the contents of the vessel.

The present invention relates to a hybrid aseptic connection system and aseptic connection method for manufacturing an antibody pharmaceutical. In a hybrid system employing a medium storage tank made of a SS material and a bioreactor made of an SU disposable tube, to ensure a completely aseptic connection between the medium storage tank and the bioreactor, the completely aseptic connection between the medium storage tank and the bioreactor may be made by interconnection of the SU disposable tube through a welding process and the advantages of both the SS system and the SU system may be obtained at the same time. As a discharge line, an SU disposable tube and a steam trap tube are formed in a “Y” shape, the flowability in a medium transfer line may be improved and thus it is possible to prevent impurities such as a condensate from remaining in the medium transfer line.

A stem cell manufacturing system for manufacturing stem cells from somatic cells includes: one or more closed production device(s) configured to produce stem cells from somatic cells; one or more drive device(s) configured to be connected with the production device(s) and drive the production device(s) in such a manner as to maintain the production device(s) in an environment suitable for producing stem cells; one or more cryopreservation device(s) configured to cryopreserve the produced stem cells; a first memory device configured to store whether or not somatic cells have been introduced to the production device(s), as a first state; a second memory device configured to store whether or not the production device(s) is/are connected with the drive device(s), as a second state; and a third memory device configured to store whether or not the produced stem cells can be placed in the cryopreservation device(s), as a third state.