The current disclosure concerns a method for decontaminating a virus production system, wherein virus particles are produced in at least one bioreactor and purified from liquids comprising said virus particles thereby generating liquid waste, said method comprising the step of exposing said system or a part thereof to heated air and/or liquid at a temperature of at least 60° C. after viral production took place, thereby eradicating remaining virus particles in said system. In a second and third aspect the current disclosure concerns a virus production system wherein the system comprises a heating device suitable for heating air and/or liquid to a temperature of at least 60° C., and the use of such a system for the production of viruses and/or viral vaccines.

A virus inactivation method is provided. The method includes irradiating a solution containing an artificially expressed antibody or antibody fragment with ultraviolet rays in the presence of a radical scavenger. The irradiating only aggregates 5% or less of the antibody or antibody fragment. A wavelength of the ultraviolet rays is 200 nm or longer and 315 nm or shorter. An irradiation amount of the ultraviolet rays is 300 mJ/cm.sup.2 or more. An irradiation time of the ultraviolet rays is 3 minutes or less. A concentration of the radical scavenger in the solution is 0.03 mM or more.

Provided is a culture device, including: a culture tank (110) configured to store an object liquid that is a culture solution having suspended therein an object; a screen (210) made of a metal, the screen including a main body (212) and a plurality of through holes (214) passing through the main body from a front surface (212a) thereof to a back surface (212b) thereof; a spray portion (220) configured to spray the object liquid stored in the culture tank onto the front surface of the body; an accommodation portion (240) surrounding the back surface of the main body and configured to accommodate the culture solution having passed through the through holes; a UV light irradiation portion (250) arranged in the accommodation portion and configured to radiate UV light; and a return portion (290) configured to return the culture solution in the accommodation portion to the culture tank.

A facility for the recycling of biomaterial with a fermentation stage, whereby the fermentation stage has a fermentation chamber for the production of biogas through anaerobic fermentation of the biomaterial, and with a hygiene stage that is positioned downstream from the fermentation stage, whereby the hygiene stage has a hygienization chamber for the reception and the thermal hygienization of biomaterial discharged from the fermentation stage. A process for the recycling of biomaterial by zymosis is also provided, whereby biogas is produced in a fermentation stage through anaerobic fermentation of the biomaterial, whereby the biomaterial is, after flowing through the fermentation stage, conveyed to a hygiene stage in which the biomaterial thermal is hygienized, and whereby the biomaterial is, after flowing through the hygiene stage, made available as recyclable agricultural, hygienized fermentation residue.

An incubator (1) and its use for cultivating microorganisms and/or for carrying out a chemical reaction are provided. The incubator (1) has a sample vessel holder (3) for insertion of a sample vessel (4), a heating device (5) for changing a temperature in the sample vessel holder (3) and/or in a sample vessel (4) inserted into the sample vessel holder (3), and a sample-inactivating device (6) for inactivation of a sample (7) in a sample vessel (4) that is inserted into the sample vessel holder (3).

Provided is a culture device, including: a culture tank (110) configured to store an object liquid that is a culture solution having suspended therein an object; a screen (210) made of a metal, the screen including a main body (212) and a plurality of through holes (slits (214)) passing through the main body (212) from a front surface (212a) thereof to a back surface (212b) thereof; a spray portion (220) configured to spray the object liquid stored in the culture tank onto the front surface of the main body (212); an accommodation portion (240) surrounding the back surface (212b) of the main body (212) and configured to accommodate the culture solution having passed through the through holes; a UV light irradiation portion (250) arranged in the accommodation portion (240) and configured to radiate UV light; and a return portion (290) configured to return the culture solution in the accommodation portion (240) to the culture tank.

The invention provides a method for the continuous, microbe-reduced production and/or processing of a biopharmaceutical, biological macromolecular product from a heterogeneous cell culture-fluid mixture, comprising the steps of: (a) providing a particle-free fluid from a heterogeneous cell culture-fluid mixture containing the product, in the form of a product stream, (b) at least one filtration, providing a filtrate, (c) at least two chromatography steps for purifying the product, (d) at least one virus depletion, (e) at least one ultrafiltration and/or at least one diafiltration of the product stream of steps (b), (c) and/or (d), characterized in that the at least two chromatography steps from (c) comprise a purification via at least two chromatography columns and/or membrane adsorbers in each case and that the process is carried out in a closed and modular manner The invention further provides a corresponding modular system for carrying out said method.

There is provided a safety cabinet in which a good operability is attained and it is possible to secure a sterility assurance level. There is provided a safety cabinet including an operation chamber, a front door that covers part of an opening of a front surface of the operation chamber, an operation opening below the front door, into which an operator can insert an hand and perform an operation, and a front slit, which takes in air inside the operation chamber and air in a room through the operation opening, on a front surface side of a lower portion of the operation chamber, the cabinet including sterilization gas generating means; and sealing means for sealing the operation opening during a sterilization operation.

A fiber reactor system includes a fiber slurry tank configured for receiving fiber feed containing cellulose and hemicellulose for forming a fiber slurry, which is mixed with evaporator condensate. The fiber slurry is mixed with steam vapors for sterilizing. A fiber reactor system is configured for receiving ruled fiber and mixing with microorganisms. The scrubber water is fed the top of a scrubber to capture ethanol and an ethanol-laden fiber stream is sent to a low-ethanol beer stripping system.

A continuous sterilizing apparatus circulates, through members constituting a flow channel, a sterilizing medium that sterilizes the members to sterilize the members, circulates a sterilizing liquid subjected to sterilization treatment through pipes, performs a series of pieces of treatment including heating treatment, holding treatment, and cooling treatment on the sterilizing liquid, controls a flow rate, a temperature, and a pressure to be preset conditions, and switches a liquid to be circulated through the flow channel from the sterilizing liquid to a liquid to be sterilized.