A urine analyzer device, configured to be installed in a toilet bowl, to be used several times, the device comprising a holder member, to attach the device to the rim of the toilet bowl, an electronic unit, enclosed in a housing, a urine reception area, with at least one electro-chemical sensor, configured to measure a quantity of at least one substance contained in urine, such as physiological compound or chemical component, a wireless coupler to send resulting data to a remote computing device, wherein the electro-chemical sensor comprises at least a ion selective Field Effect Transistor (ISFET), configured to sense levels of one or more physiological ions, thereby providing a urine analyzer device, readily available at home, simply installed in a toilet bowl, and that can be used several times subsequently.

A biosensor for detecting analytes present in fluid includes one or more plates configured on a substrate to form at least one channel such that one or more containment chambers are formed in the channels. The channel are mechanically, separated from each other by spacers, and the containment chambers are fluidically separated from adjacent chamber by a discontinuity such that the fluid flows between adjacent chambers only after an application of a predefined pressure on the plate. The multiple chambers allows the fluid to undergo pre-processing using different set of reagents provided at different chambers, to mitigate effects of interferents and to efficiently distribute load of the reagents on the chambers. Further, some of containment chambers allows detection of analytes in the fluid using detection reagents.

The present disclosure provides a biochemical test chip, including an insulating substrate, an electrode unit, a first insulating septum, a reactive layer and a second insulating septum. The electrode unit is located on the insulating substrate. The electrode unit includes a working electrode and a counter electrode. A current density of the counter electrode is greater than a current density of the working electrode. The first insulating septum is located on the electrode unit. The first insulating septum has an opening, which at least partially exposes the electrode unit. The reactive layer is located in the opening and is electrically connected to the electrode unit. The second insulating septum is located on the first insulating septum.

A method comprises printing a conductive ink on a substrate to form one or more electrodes and printing an electrode ink on one or more of the electrodes. The conductive and electrode inks are cured. Next, an enzyme ink layer is printed on at least one electrode, and the enzyme ink layer is cured with ultraviolet light. Each of the printing and curing processes are performed in an in-line process.

In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.

A sensor comprising an elongate member comprising an electrochemical sensor comprising an electrochemical filament extending along the length of the elongate member, wherein the elongate member comprises a fibre formed from a drawable material.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.