The invention relates to a method for detecting organisms in a liquid sample, comprising the provision of a capture area including particles in a liquid medium and subjected to a hydrodynamic flow, wherein the organisms to be detected are capable of binding to these particles, the method comprising the steps of: (a) circulating the sample through the capture area; (b) circulating a growth medium through the capture area; and (c) determining the presence, nature or concentration of organisms in the capture area; said particles being retained in the capture area as a fluidized bed for at least one part of these steps.

The invention also relates to a system for implementing this method.

The invention relates to a method for detecting organisms in a liquid sample, comprising the provision of a capture area including particles in a liquid medium and subjected to a hydrodynamic flow, wherein the organisms to be detected are capable of binding to these particles, the method comprising the steps of: (a) circulating the sample through the capture area; (b) circulating a growth medium through the capture area; and (c) determining the presence, nature or concentration of organisms in the capture area; said particles being retained in the capture area as a fluidized bed for at least one part of these steps. The invention also relates to a system for implementing this method.

A method and device for detection of specific bacteria of interest by monitoring for chemical changes in media using electrical circuits. The present invention provides an inexpensive method to detect and measure particular bacteria of interest in samples, and is useful in particular as a means of monitoring for contamination in water sources.

The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.

The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.

The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.

The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion includes an electrode system, and the nucleic acid molecule to be evaluated is arranged on the base is used. In the present invention, it is preferred that a plurality of kinds of nucleic acid molecule to be evaluated is arranged on the base, and the plurality of kinds of nucleic acid molecules to be evaluated is evaluated by a single device.

In the clinic, most patients' cancer tissues have a heterogeneous histological appearance, often as a result of newly emerging and resistant cancer cell populations. Thus, viability tests to detect the sensitivity of a cancer tissue might not accurately predict a patient's tumor response if smaller but resistant cancer cells proliferate and replace the cells that are sensitive to the current treatment. Provided are methods to multiplex the detection of cell viability and proliferation in a single sample. A cell or tissue sample is treated, incubated with a glycosylamine, and subsequently washed. The sample is then permeabilized, and a first detectable marker is measured to quantify viability effects while a second detectable marker is measured to quantify proliferative effects. These methods may be used to more reliably predict treatment effects for a cancer patient and to evaluate a biological effect of a therapy on malignant viable cells.