The disclosure relates to particle-based assays for the detection of analytes. Using various combinations of particular technologies, including gold nanorods, silver nanoparticles, gold/silver nanoshells, gold/silver nanocages and nanobubble detection, enhanced detection limits can be achieved across a large range of analytes.

A method of sensing molecules using a detection device, the detection device comprising a plurality of magnetoresistive (MR) sensors and at least one fluidic channel, comprising adding a plurality of molecules to be detected to the at least one fluidic channel, wherein at least some of the plurality of molecules to be detected are coupled to respective magnetic nanoparticles (MNPs), detecting a characteristic of a magnetic noise of a first MR sensor of the plurality of MR sensors, wherein the characteristic of the magnetic noise is influenced by a presence of one or more MNPs in a vicinity of the first MR sensor, and determining, based on the detected characteristic, whether the first MR sensor detected the presence of one or more MNPs in the vicinity of the first MR sensor.

A method of sensing molecules using a detection device, the detection device comprising a plurality of magnetoresistive (MR) sensors and at least one fluidic channel, comprising adding a plurality of molecules to be detected to the at least one fluidic channel, wherein at least some of the plurality of molecules to be detected are coupled to respective magnetic nanoparticles (MNPs), detecting a characteristic of a magnetic noise of a first MR sensor of the plurality of MR sensors, wherein the characteristic of the magnetic noise is influenced by a presence of one or more MNPs in a vicinity of the first MR sensor, and determining, based on the detected characteristic, whether the first MR sensor detected the presence of one or more MNPs in the vicinity of the first MR sensor.

The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens.

The present disclosure relates to a nanotechnology-based molecular sensing system, compositions, and methods that can be adapted to accurately detect a target gene in clinical samples, using anti-sense oligonucleotide capped plasmonic nanoparticles for selective detection of biological pathogens.

A method for sequencing a nucleic acid template includes forming a nanowire assembly including a semiconductor nanowire and a probe covalently bound to the semiconductor nanowire; contacting the nanowire assembly with a template nucleic acid; contacting the nucleic acid duplexes with an extension nucleic acid, the extension nucleic acid joined to the probe; disrupting the nucleic acid duplexes; and measuring an electrical characteristic of a nanowire assembly of the set of nanowire assemblies.

A method for sequencing a nucleic acid template includes forming a nanowire assembly including a semiconductor nanowire and a probe covalently bound to the semiconductor nanowire; contacting the nanowire assembly with a template nucleic acid; contacting the nucleic acid duplexes with an extension nucleic acid, the extension nucleic acid joined to the probe; disrupting the nucleic acid duplexes; and measuring an electrical characteristic of a nanowire assembly of the set of nanowire assemblies.

The present invention pertains to the field of pre-functionalised nanoparticles (NPs). It relates more particularly to NPs pre functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, tool for depleting a molecule of interest in a solution, and therapeutic tool.

The present invention pertains to the field of pre-functionalised nanoparticles (NPs). It relates more particularly to NPs pre functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, tool for depleting a molecule of interest in a solution, and therapeutic tool.

The present invention provides a paper-based, nucleic acid-detecting sensor capable of easily and simply detecting the presence of a target nucleic acid from a PCR amplicon. In addition, the present invention provides a paper-based, nucleic acid-detecting kit capable of easily and simply detecting the presence of a target nucleic acid from a PCR amplicon and a nucleic acid detecting method using same. The present invention can easily and simply determine the presence or absence of a target nucleic acid in a PCR amplicon by utilizing the function in which the target nucleic acid is associated with nanoparticles to form a composite and when loaded into the sensor, the composite is separated and moves according to the structure of the sensor and is finally visualized on the sensor.