The present invention relates to a method for diagnosing a degradation of esthetic qualities of the skin, based on a measurement of the level of expression of the gene encoding FLG2. The present invention also relates to a method for the cosmetic treatment of skin. The present invention also relates to a method for identifying a compound for reducing and/or slowing the degradation of esthetic quality of the skin, and a kit.

Compositions and methods are provided to enrich for DNA corresponding to a genome of interest, e.g. by species, clade, or strain of origin, from a mixed population of nucleic acid sequences. The methods may further comprise identification of the genomic sequences of interest, e.g. identifying the species, clade, strain, etc. of origin.

Disclosed is a method for evaluating a cosmetic composition or a component thereof, comprising the steps of: (i) identifying a first individual microbiome network on a skin surface of a person; (ii) treating the skin surface having the identified first individual microbiome network with a cosmetic composition or the component thereof; (iii) identifying a second individual microbiome network on the skin surface that was treated; and (iv) comparing the first and second individual microbiome networks.

The disclosure introduces a paradigm-shifting method and system for capitalizing on the expansive datasets generated from medical and biological research, employing a refined artificial intelligence framework designed to enhance individual well-being through personalized solutions. The disclosed system includes a sophisticated analytical engine adept at amalgamating and deciphering biologic data from genetic, environmental, and lifestyle sources to inform a diverse array of decisions spanning the healthcare and consumer product industries. The biologic data is processed using one or more neural networks, a mixture-of-expert models, or a combination of both. The neural networks and expert models are engineered to pinpoint essential biomarkers and interpret complex biologic datasets, thereby yielding actionable insights for personalized response determination. The utility of the system extends beyond the theoretical and ventures into the tangible, affecting everyday life.

The present invention relates to a method for identifying biological markers for characterizing children's skin. The method of the invention thus makes it possible to identify molecular markers that are expressed differently in children's skin than in the skin of adults. The present invention therefore enables the skin to be characterized at the molecular level from birth and the changes thereof with age to be tracked.