The present disclosure relates to crystalline solids comprising a compound of Formula (I), ##STR00001##
wherein R is n-propyl, and methods of making compounds of Formula (I) wherein R is C1-C4 alkyl or C2-C4 alkenyl. The present disclosure also relates to crystalline solids comprising a compound of Formula (II), ##STR00002## The present disclosure further relates to methods of preparing the crystalline solids, and pharmaceutical preparations of the crystalline solids, and use of such pharmaceutical preparations in treatment of diseases and conditions.

The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.

The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer (10), wherein crystallization by evaporation and/or crystallization by cooling is carried out continuously on a crystal suspension in the main crystallizer in order to allow crystals of the monosaccharide to grow in the crystal suspension; separation of crystals of the monosaccharide out of the crystal suspension to obtain crystalline monosaccharide; continuous formation of a mass of crystallization magma for the main crystallizer (10) in a cascade, wherein the cascade comprises at least one first stage (13) and a final stage (15) connected in series and each stage comprises at least one pre-crystallizer (13A, 15A), wherein, in the at least one pre-crystallizer (13A) of the first stage (13), a solution is seeded with monosaccharide by means of monosaccharide seed crystals in order to obtain a pre-crystallization magma, and a mass of crystallization magma for the downstream stage (14, 15) is formed from the pre-crystallization magma by means of crystallization by cooling and/or crystallization by evaporation, and wherein a solution containing monosaccharide and a mass of crystallization magma from the upstream stage is supplied to the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) to obtain a pre-crystallization magma, and in the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) a mass of crystallization magma for the main crystallizer (10) is formed from the pre-crystallisation magma by means of crystallization by cooling and/or crystallization by evaporation; the continuous supply of a solution containing the monosaccharide and a mass of crystallization magma from the at least one pre-crystallizer (15A, 15B, 15C) of the final stage (15) of the cascade to the main crystallizer (10) to provide the crystal suspension.

The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

A preparation method of phosphotungstic acid includes mixing a mixed solution containing tungsten, phosphorus and an inorganic acid with an organic-alcohol-containing oil phase for extraction, stripping the obtained supported organic phase and distilled water according to an oil phase:aqueous phase volume ratio of 3:1 to 10:1 to obtain a stripping solution; and carrying out thermal evaporation crystallization or spray drying on the stripping solution to obtain a phosphotungstic acid crystal, wherein the organic alcohol is a C7-C20 alcohol. The inventors have found out that the addition of an inorganic acid to a solution of phosphorus or tungsten and the use of an organic alcohol as an extractant can achieve simultaneous and efficient extraction of phosphotungstic acid. It has also been found that the organic-alcohol-containing oil phase has excellent selectivity for phosphotungstic acid molecules in the mixed solution.

A novel one-pot solvothermal reaction based on urea hydrolysis to synthesize single crystals of the Zn(NH.sub.3)(CO.sub.3) inorganic helical framework and its applications in selective CO.sub.2 separation.

An electrostatic levitation crystal growth apparatus for a solution and a crystal growing method using the same. The apparatus may include an upper electrode, a lower electrode vertically spaced apart from the upper electrode, a power supply unit configured to apply a vertical electrostatic field between the upper electrode and the lower electrode, and a droplet dispenser configured to eject a solution into a region between the upper and lower electrodes and thereby to form a solution droplet. The solution droplet may be maintained in a charged state and may be electrostatically levitated against the gravity exerted thereon, by the vertical electrostatic field. The solution droplet may be evaporated in the electrostatically levitated state, and a solute dissolved in the solution may be grown to form a crystal.

An electrostatic levitation crystal growth apparatus for a solution and a crystal growing method using the same. The apparatus may include an upper electrode, a lower electrode vertically spaced apart from the upper electrode, a power supply unit configured to apply a vertical electrostatic field between the upper electrode and the lower electrode, and a droplet dispenser configured to eject a solution into a region between the upper and lower electrodes and thereby to form a solution droplet. The solution droplet may be maintained in a charged state and may be electrostatically levitated against the gravity exerted thereon, by the vertical electrostatic field. The solution droplet may be evaporated in the electrostatically levitated state, and a solute dissolved in the solution may be grown to form a crystal.

A transparent conductor including a conductive layer coated on a substrate is described. More specifically, the conductive layer comprises a network of nanowires which may be embedded in a matrix. The conductive layer is optically transparent and flexible. It can be coated or laminated onto a variety of substrates, including flexible and rigid substrates.

A transparent conductor including a conductive layer coated on a substrate is described. More specifically, the conductive layer comprises a network of nanowires which may be embedded in a matrix. The conductive layer is optically transparent and flexible. It can be coated or laminated onto a variety of substrates, including flexible and rigid substrates.