The invention relates to a method for producing a specific hydroxy compound by decarboxylating a specific carboxylic acid compound or a salt of said carboxylic acid compound in the presence of a Bronsted base. The invention also relates to a method for producing a diaryl carbonate or a bisphenol, to a method for producing a polycarbonate and to a use of a Bronsted base during the reaction of the decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound.

The invention relates to a method for producing a specific hydroxy compound by decarboxylating a specific carboxylic acid compound or a salt of said carboxylic acid compound in the presence of a Bronsted base. The invention also relates to a method for producing a diaryl carbonate or a bisphenol, to a method for producing a polycarbonate and to a use of a Bronsted base during the reaction of the decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound.

The present invention relates to intermediate compounds for the synthesis of novel cannabinoids 1 and 2, synthesized from simple starting materials using a cascade sequence of allylic rearrangement, aromatization and, for tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2 are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ.sup.8-tetrahydrocannabinol. The analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis oil.

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Novel compounds of the formulas 3 and 6, useful as intermediates for the synthesis of the cannabinoids of advanced intermediates 4 and 5 as well as cannabinoids of the formulas 1 and 2, are disclosed.

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The present invention relates to intermediate compounds for the synthesis of novel cannabinoids 1 and 2, synthesized from simple starting materials using a cascade sequence of allylic rearrangement, aromatization and, for tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2 are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ.sup.8-tetrahydrocannabinol. The analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis oil.

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Novel compounds of the formulas 3 and 6, useful as intermediates for the synthesis of the cannabinoids of advanced intermediates 4 and 5 as well as cannabinoids of the formulas 1 and 2, are disclosed.

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A waterless decarboxylation device used to decarboxylate cannabis is described. For example, the device could include a product container to contain an amount of raw cannabis plant material, a heating container configured to surround and contact the product container, a heater in contact with the heating container, a foam layer surrounding the product container and heating container, at least one sensor configured to detect the temperature of the heating container, a lid that encloses the product container and fluidly seals it from the environment, and a controller configured to control power to the heater in response to signals sent from the at least one sensor indicating whether the heating container has reached a threshold temperature.

A waterless decarboxylation device used to decarboxylate cannabis is described. For example, the device could include a product container to contain an amount of raw cannabis plant material, a heating container configured to surround and contact the product container, a heater in contact with the heating container, a foam layer surrounding the product container and heating container, at least one sensor configured to detect the temperature of the heating container, a lid that encloses the product container and fluidly seals it from the environment, and a controller configured to control power to the heater in response to signals sent from the at least one sensor indicating whether the heating container has reached a threshold temperature.

Provided is a method of decomposing phenol-based by-product, and more particularly, a method of decomposing phenol-based by-product including: introducing a phenol-based by-product stream, a first stream of a side discharge stream from a decomposition device, and a process water stream to a mixing device and mixing the streams; introducing a discharge stream from the mixing device to a layer separation device to phase-separate the discharge stream into an oil phase and an aqueous phase; passing an oil stream discharged from the layer separation device through any one or more of a first heat exchanger and a second heat exchanger and introducing the oil stream to the decomposition device to carry out decomposition; and supplying the first stream of the side discharge stream from the decomposition device to the mixing device, forming a mixed stream of a second stream of the side discharge stream with a lower discharge stream and discharging the mixed stream, and recovering effective components from an upper discharge stream.

Provided is a method of decomposing phenol-based by-product, and more particularly, a method of decomposing phenol-based by-product including: introducing a phenol-based by-product stream, a first stream of a side discharge stream from a decomposition device, and a process water stream to a mixing device and mixing the streams; introducing a discharge stream from the mixing device to a layer separation device to phase-separate the discharge stream into an oil phase and an aqueous phase; passing an oil stream discharged from the layer separation device through any one or more of a first heat exchanger and a second heat exchanger and introducing the oil stream to the decomposition device to carry out decomposition; and supplying the first stream of the side discharge stream from the decomposition device to the mixing device, forming a mixed stream of a second stream of the side discharge stream with a lower discharge stream and discharging the mixed stream, and recovering effective components from an upper discharge stream.

Provided is a method of decomposing phenol-based by-product, and more particularly, a method of decomposing phenol-based by-product including: introducing a phenol-based by-product stream, a first stream of a side discharge stream from a decomposition device, and a process water stream to a mixing device and mixing the streams; introducing a discharge stream from the mixing device to a layer separation device to phase-separate the discharge stream into an oil phase and an aqueous phase; passing an oil stream discharged from the layer separation device through any one or more of a first heat exchanger and a second heat exchanger and introducing the oil stream to the decomposition device to carry out decomposition; and supplying the first stream of the side discharge stream from the decomposition device to the mixing device, forming a mixed stream of a second stream of the side discharge stream with a lower discharge stream and discharging the mixed stream, and recovering effective components from an upper discharge stream.

A process for the preparation of substantially pure diverse known and novel cannabinoids 1 and 2, which include Δ.sup.9-tetrahydrocannabinol (7), tetrahydrocannabivarin (9), cannabidiol (11), cannabidivarin (12) and other naturally occurring tetracyclic and tricyclic cannabinoids and other synthetic tetracyclic and tricyclic analogues, via intermediates 3, 6, 4 and 5, using a cascade sequence of allylic rearrangement, aromatization and, for the tetracyclic cannabinoids, further highly stereoselective and regioselective cyclization. These synthesized cannabinoids can more easily be obtained at high purity levels than cannabinoids isolated or synthesized via known methods. The cannabinoids 2, including Δ.sup.9-tetrahydrocannabinol (7), tetrahydrocannabivarin (9), are obtained containing very low levels of isomeric cannabinoids such as the undesirable Δ8-tetrahydrocannabinol. The known and novel analogues with variation in aromatic ring substituents, whilst easily synthesized with the new methodology, would be much more difficult to make from any of the components of cannabis or cannabis oil.