Patent classifications
C07C50/28
CANCER TREATMENT USING COMPOUNDS THAT SELECTIVELY TARGET POLYPLOID CANCER CELLS FOR DISRUPTION
The disclosure provides a compound of Formula I:
##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.
CANCER TREATMENT USING COMPOUNDS THAT SELECTIVELY TARGET POLYPLOID CANCER CELLS FOR DISRUPTION
The disclosure provides a compound of Formula I:
##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as described herein. The disclosure also provides methods for identifying a compound that selectively kills polyploid cells, and methods for killing polyploid tumor cells by administering a compound of Formula I to a patient in need thereof.
SYSTEMS AND METHODS FOR PRODUCING COENZYME Q10
A system and method for purifying coenzyme Q.sub.10 are provided. The method includes: passing a CoQ.sub.10-containing crude product through a first chromatographic column to obtain a first CoQ.sub.10-containing intermediate product. The method further includes preparing, based on the first CoQ.sub.10-containing intermediate product, a second CoQ.sub.10-containing intermediate product. The method further includes passing the second CoQ.sub.10-containing intermediate product through a second chromatographic column to obtain a third CoQ.sub.10-containing intermediate product. The method further includes obtaining purified CoQ.sub.10 product by purifying the third CoQ.sub.10-containing intermediate product.
SYSTEMS AND METHODS FOR PRODUCING COENZYME Q10
A system and method for purifying coenzyme Q.sub.10 are provided. The method includes: passing a CoQ.sub.10-containing crude product through a first chromatographic column to obtain a first CoQ.sub.10-containing intermediate product. The method further includes preparing, based on the first CoQ.sub.10-containing intermediate product, a second CoQ.sub.10-containing intermediate product. The method further includes passing the second CoQ.sub.10-containing intermediate product through a second chromatographic column to obtain a third CoQ.sub.10-containing intermediate product. The method further includes obtaining purified CoQ.sub.10 product by purifying the third CoQ.sub.10-containing intermediate product.
Aminated lignin-derived compounds and uses thereof
The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.
Aminated lignin-derived compounds and uses thereof
The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.
DEUTERATED IDEBENONE
The present invention in one embodiment provides a compound of Formula I:
##STR00001##
or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.
DEUTERATED IDEBENONE
The present invention in one embodiment provides a compound of Formula I:
##STR00001##
or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.
INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES IN HERPES AND HEPATITIS VIRAL INFECTIONS THEREFOR
The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula:
##STR00001##
wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.
INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USES IN HERPES AND HEPATITIS VIRAL INFECTIONS THEREFOR
The present disclosure relates to identification of inhibitors of hepatitis and herpesvirus replication including compounds of the formula:
##STR00001##
wherein the variables are as defined herein. Also provided are methods of treatment using agents so identified.