Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.

The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicy-aldehyde compounds, processes for preparing 5-halo-3,6-dichlorosalicylic acid compounds, processes for preparing 5-halo-3,6-di-chlorosalicyaldehyde compounds, processes for preparing 3,6-dichlorosalicylic acid compounds, and processes that employ such compounds as intermediates in the preparation of the herbicide dicamba.

The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicy-aldehyde compounds, processes for preparing 5-halo-3,6-dichlorosalicylic acid compounds, processes for preparing 5-halo-3,6-di-chlorosalicyaldehyde compounds, processes for preparing 3,6-dichlorosalicylic acid compounds, and processes that employ such compounds as intermediates in the preparation of the herbicide dicamba.

The present invention relates generally to the field of chemical synthesis. Specifically, the present invention relates to a method for purification of -hydroxyl--methyl butyrate comprising (1) neutralizing a crude -hydroxyl--methyl butyrate; (2) cooling and crystallizing the crude -hydroxyl--methyl butyrate solution to create a -hydroxyl--methyl butyrate salt; (3) dissolving and acidifying the salt; and (4) extracting the resultant high purity -hydroxyl--methyl butyrate. Additionally, the present invention relates to a method of obtaining high purity -hydroxyl--methyl butyrate at normal temperature and vacuum conditions.

The present invention relates generally to the field of chemical synthesis. Specifically, the present invention relates to a method for purification of -hydroxyl--methyl butyrate comprising (1) neutralizing a crude -hydroxyl--methyl butyrate; (2) cooling and crystallizing the crude -hydroxyl--methyl butyrate solution to create a -hydroxyl--methyl butyrate salt; (3) dissolving and acidifying the salt; and (4) extracting the resultant high purity -hydroxyl--methyl butyrate. Additionally, the present invention relates to a method of obtaining high purity -hydroxyl--methyl butyrate at normal temperature and vacuum conditions.

The present invention relates generally to the field of chemical synthesis. Specifically, the present invention relates to a method for purification of -hydroxyl--methyl butyrate comprising (1) neutralizing a crude -hydroxyl--methyl butyrate; (2) cooling and crystallizing the crude -hydroxyl--methyl butyrate solution to create a -hydroxyl--methyl butyrate salt; (3) dissolving and acidifying the salt; and (4) extracting the resultant high purity -hydroxyl--methyl butyrate. Additionally, the present invention relates to a method of obtaining high purity -hydroxyl--methyl butyrate at normal temperature and vacuum conditions.

A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.

A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.