A process is provided for preparing 4-(8-(2-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)bicyclo[2.2.1]heptan-1-ol and novel intermediates used in the process. The compound is a 11-beta hydroxysteroid dehydrogenase type I inhibitor which exhibits activity in the treatment of various metabolic diseases.

The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R.sub.1 represents H or (C.sub.1-C.sub.5) alkyl groups and R.sub.2 represents (C.sub.1-C.sub.5) alkyl groups. ##STR00001##

The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R.sub.1 represents H or (C.sub.1-C.sub.5) alkyl groups and R.sub.2 represents (C.sub.1-C.sub.5) alkyl groups. ##STR00001##

The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R.sub.1 represents H or (C.sub.1-C.sub.5) alkyl groups and R.sub.2 represents (C.sub.1-C.sub.5) alkyl groups. ##STR00001##

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I). ##STR00001##

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I). ##STR00001##