The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or fluorescent imaging.

The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or fluorescent imaging.

The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or fluorescent imaging.

This disclosure relates to a method of continuous recovery of (meth)acrylic acid and an apparatus used for the recovery method. The method of continuous recovery of (meth)acrylic acid according to the present invention may effectively remove scum formed in the continuous recovery process of (meth)acrylic acid, and simultaneously recover (meth)acrylic acid with excellent efficiency, thus enabling more stable operation of the continuous process.

This disclosure relates to a method of continuous recovery of (meth)acrylic acid and an apparatus used for the recovery method. The method of continuous recovery of (meth)acrylic acid according to the present invention may effectively remove scum formed in the continuous recovery process of (meth)acrylic acid, and simultaneously recover (meth)acrylic acid with excellent efficiency, thus enabling more stable operation of the continuous process.

This disclosure relates to a method of continuous recovery of (meth)acrylic acid and an apparatus used for the recovery method. The method of continuous recovery of (meth)acrylic acid according to the present invention may effectively remove scum formed in the continuous recovery process of (meth)acrylic acid, and simultaneously recover (meth)acrylic acid with excellent efficiency, thus enabling more stable operation of the continuous process.

A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification.

##STR00001##

A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification.

##STR00001##

A method of producing higher alkanones, preferably 6-undecanone, from ethanol and/or acetate, may include: (a) contacting the ethanol and/or acetate with at least one microorganism capable of carrying out carbon chain elongation to produce hexanoic acid and/or an ester thereof from the ethanol and/or acetate; (b) extracting the hexanoic acid and/or ester thereof from the contacting (a) using at least one extractant in an aqueous medium, the extractant including at least one alkyl-phosphine oxide and at least one C12+ alkane; or at least one trialkylamine and at least one C12+ alkane; and (c) contacting the extracted hexanoic acid and/or ester thereof from (b) with at least one ketonization catalyst and eventually a further C1 to C22 alkanoic acid under suitable reaction conditions for chemical ketonization of hexanoic acid and eventually the further alkanoic acid to a higher alkanone, preferably 6-undecanone.

A method of producing higher alkanones, preferably 6-undecanone, from ethanol and/or acetate, may include: (a) contacting the ethanol and/or acetate with at least one microorganism capable of carrying out carbon chain elongation to produce hexanoic acid and/or an ester thereof from the ethanol and/or acetate; (b) extracting the hexanoic acid and/or ester thereof from the contacting (a) using at least one extractant in an aqueous medium, the extractant including at least one alkyl-phosphine oxide and at least one C12+ alkane; or at least one trialkylamine and at least one C12+ alkane; and (c) contacting the extracted hexanoic acid and/or ester thereof from (b) with at least one ketonization catalyst and eventually a further C1 to C22 alkanoic acid under suitable reaction conditions for chemical ketonization of hexanoic acid and eventually the further alkanoic acid to a higher alkanone, preferably 6-undecanone.