A process, a system, and an apparatus are provided for converting a lower alkane to an alkene. Oxygen and the lower alkane are provided to an ODH reactor to convert at least a portion of the lower alkane to an alkene. An ODH stream comprising the alkene, an oxygenate, steam, and a carbon-based oxide is produced. The bulk of the oxygenate is removed from the ODH outlet stream by non-dilutive cooling, with residual oxygenate being removed using dilutive quenching with a carbonate. Subsequently, separation of the carbon-based oxide from the alkene is achieved using a caustic tower, which also produces spent caustic in the form of a carbonate, which is then used as the carbonate for dilutive quenching. Dilutive quenching using a carbonate allows conversion of the oxygenate to an acetate, which can then be used to simplify separation of the oxygenate from water.

A process, a system, and an apparatus are provided for converting a lower alkane to an alkene. Oxygen and the lower alkane are provided to an ODH reactor to convert at least a portion of the lower alkane to an alkene. An ODH stream comprising the alkene, an oxygenate, steam, and a carbon-based oxide is produced. The bulk of the oxygenate is removed from the ODH outlet stream by non-dilutive cooling, with residual oxygenate being removed using dilutive quenching with a carbonate. Subsequently, separation of the carbon-based oxide from the alkene is achieved using a caustic tower, which also produces spent caustic in the form of a carbonate, which is then used as the carbonate for dilutive quenching. Dilutive quenching using a carbonate allows conversion of the oxygenate to an acetate, which can then be used to simplify separation of the oxygenate from water.

A calcium carboxylate is prepared by reacting water, calcium oxide, and a compound of formula (I):

##STR00001##

wherein R is a C.sub.1-C.sub.3 alkyl and R.sub.1 is a C.sub.1 or C.sub.2 alkyl. The reaction solution is heated to remove an amount of a co-product from the reaction solution. The calcium carboxylate may be recovered in a solid form from the reaction solution.

A calcium carboxylate is prepared by reacting water, calcium oxide, and a compound of formula (I):

##STR00001##

wherein R is a C.sub.1-C.sub.3 alkyl and R.sub.1 is a C.sub.1 or C.sub.2 alkyl. The reaction solution is heated to remove an amount of a co-product from the reaction solution. The calcium carboxylate may be recovered in a solid form from the reaction solution.

A quaternary ammonium salt of formula (I): wherein X is a linking group; Y is O, NH or NR.sup.1 wherein R.sup.1 is H or an optionally substituted hydrocarbyl group; Q.sup.+ is a moiety that includes a quaternary ammonium cation; A.sup.− is an anion; R.sup.2 is an optionally substituted alkylene group; R.sup.3 is hydrogen or an optionally substituted hydrocarbyl group; and n is 0 or a positive integer; provided that n is not 0 when R.sup.3 is hydrogen. ##STR00001##

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

An organically modified metal oxide nanoparticles that can be produced by a simple method and can increase the sensitivity and resolution of a resist material. The EUV photoresist material contains organically modified metal oxide nanoparticles and a solvent. The organically modified metal oxide nanoparticles include a core, a first modification group, and a second modification group. The core includes a plurality of metal atoms and a plurality of oxygen atoms bonded to the plurality of metal atoms. The first modification group is a carboxylic acid carboxylate ligand coordinated to the core. The second modification group is a carboxylic acid carboxylate ligand coordinated to the core and having a smaller molecular weight than the first modification group and/or an inorganic anion smaller in size than the first modification group.

The method of the disclosure comprises fermenting a gas substrate and a microorganism to generate a fermentation broth comprising the microorganism and the target component; passing the fermentation broth to a separation unit having an ion exchange resin in a continuous ion exchange simulated moving bed; selectively retaining the target component through ion exchange with the resin while passing the microorganism through the bed; regenerating the ion exchange resin; and recovering the target component. Alternatively, the fermentation broth is passed to a first separation zone to separate and recycle a first portion of the fermentation broth comprising the microorganism to the bioreactor and then a second portion of the fermentation broth is passed to a second separation zone comprising ion exchange resin which selectively retains the target component through ion exchange with the resin. The remainder is passed through. The ion exchange resin is regenerated, and the target component recovered.

The method of the disclosure comprises fermenting a gas substrate and a microorganism to generate a fermentation broth comprising the microorganism and the target component; passing the fermentation broth to a separation unit having an ion exchange resin in a continuous ion exchange simulated moving bed; selectively retaining the target component through ion exchange with the resin while passing the microorganism through the bed; regenerating the ion exchange resin; and recovering the target component. Alternatively, the fermentation broth is passed to a first separation zone to separate and recycle a first portion of the fermentation broth comprising the microorganism to the bioreactor and then a second portion of the fermentation broth is passed to a second separation zone comprising ion exchange resin which selectively retains the target component through ion exchange with the resin. The remainder is passed through. The ion exchange resin is regenerated, and the target component recovered.