A method for preparing glycolic acid through hydrolysis of alkoxyacetate is provided. The method includes: subjecting raw materials including the alkoxyacetate and water to a reaction in the presence of an acidic molecular sieve catalyst to produce the glycolic acid, where the alkoxyacetate is at least one selected from the group consisting of compounds with a structural formula shown in formula I; and in formula I, R.sub.1 and R.sub.2 each are independently any one selected from the group consisting of C.sub.1-C.sub.5 alkyl groups. The glycolic acid production method in the present application can be implemented by a traditional fixed-bed reactor under an atmospheric pressure, which is very suitable for continuous production.

A method for preparing glycolic acid through hydrolysis of alkoxyacetate is provided. The method includes: subjecting raw materials including the alkoxyacetate and water to a reaction in the presence of an acidic molecular sieve catalyst to produce the glycolic acid, where the alkoxyacetate is at least one selected from the group consisting of compounds with a structural formula shown in formula I; and in formula I, R.sub.1 and R.sub.2 each are independently any one selected from the group consisting of C.sub.1-C.sub.5 alkyl groups. The glycolic acid production method in the present application can be implemented by a traditional fixed-bed reactor under an atmospheric pressure, which is very suitable for continuous production.

A method for preparing glycolic acid through hydrolysis of alkoxyacetate is provided. The method includes: subjecting raw materials including the alkoxyacetate and water to a reaction in the presence of an acidic molecular sieve catalyst to produce the glycolic acid, where the alkoxyacetate is at least one selected from the group consisting of compounds with a structural formula shown in formula I; and in formula I, R.sub.1 and R.sub.2 each are independently any one selected from the group consisting of C.sub.1-C.sub.5 alkyl groups. The glycolic acid production method in the present application can be implemented by a traditional fixed-bed reactor under an atmospheric pressure, which is very suitable for continuous production.

A method and a system for producing glycolic acid and/or glycolate from sustainable resources. A method for catalytic production of glycolic acid and/or glycolate including the step of: oxidation of a starting material including between 0.1-100 wt/wt % glycolaldehyde at a temperature of between 10 C. and 100 C. with an oxidant in the presence of a metal-based catalyst including a catalytically active metal, which is selected from the group of palladium and platinum; or mixtures thereof.

A method and a system for producing glycolic acid and/or glycolate from sustainable resources. A method for catalytic production of glycolic acid and/or glycolate including the step of: oxidation of a starting material including between 0.1-100 wt/wt % glycolaldehyde at a temperature of between 10 C. and 100 C. with an oxidant in the presence of a metal-based catalyst including a catalytically active metal, which is selected from the group of palladium and platinum; or mixtures thereof.

A method and a system for producing glycolic acid and/or glycolate from sustainable resources. A method for catalytic production of glycolic acid and/or glycolate including the step of: oxidation of a starting material including between 0.1-100 wt/wt % glycolaldehyde at a temperature of between 10 C. and 100 C. with an oxidant in the presence of a metal-based catalyst including a catalytically active metal, which is selected from the group of palladium and platinum; or mixtures thereof.

A process for the production of glycolic acid or a derivative thereof comprises: reacting formaldehyde with carbon monoxide and water in a carbonylation reactor in the presence of a sulfurcatalyst, said reactor operating under suitable conditions, such that glycolic acid is formed; recovering a first product stream comprising glycolic acid, impurities and a sulfur species in the carbonylation reactor; passing the first product stream to an esterification reactor where it is subjected to esterification to form an alkylglycolate and wherein the esterification is catalysed by the sulfur species recovered in the first product stream; recovering a second product stream comprising the alkylglycolate, sulfur species and impurities from the esterification reactor; separating the sulfur species from the second product stream and recycling it to the carbonylation reactor in step (a) to form a sulphur depleted second product stream; separating the alkylglycolate from the sulphur depleted second product stream in a distillation zone; and recovering the alkylglycolate and converting the alkylglycolate to glycolic acid.

A process for the production of glycolic acid or a derivative thereof comprises: reacting formaldehyde with carbon monoxide and water in a carbonylation reactor in the presence of a sulfurcatalyst, said reactor operating under suitable conditions, such that glycolic acid is formed; recovering a first product stream comprising glycolic acid, impurities and a sulfur species in the carbonylation reactor; passing the first product stream to an esterification reactor where it is subjected to esterification to form an alkylglycolate and wherein the esterification is catalysed by the sulfur species recovered in the first product stream; recovering a second product stream comprising the alkylglycolate, sulfur species and impurities from the esterification reactor; separating the sulfur species from the second product stream and recycling it to the carbonylation reactor in step (a) to form a sulphur depleted second product stream; separating the alkylglycolate from the sulphur depleted second product stream in a distillation zone; and recovering the alkylglycolate and converting the alkylglycolate to glycolic acid.

A process for the production of glycolic acid or a derivative thereof comprises: reacting formaldehyde with carbon monoxide and water in a carbonylation reactor in the presence of a sulfurcatalyst, said reactor operating under suitable conditions, such that glycolic acid is formed; recovering a first product stream comprising glycolic acid, impurities and a sulfur species in the carbonylation reactor; passing the first product stream to an esterification reactor where it is subjected to esterification to form an alkylglycolate and wherein the esterification is catalysed by the sulfur species recovered in the first product stream; recovering a second product stream comprising the alkylglycolate, sulfur species and impurities from the esterification reactor; separating the sulfur species from the second product stream and recycling it to the carbonylation reactor in step (a) to form a sulphur depleted second product stream; separating the alkylglycolate from the sulphur depleted second product stream in a distillation zone; and recovering the alkylglycolate and converting the alkylglycolate to glycolic acid.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.