A method for the catalytic conversion of ketoacids, including methods for increasing the molecular weight of ketoacids, the method comprising the steps of providing in a reactor a feedstock comprising at least one ketoacid. The feedstock is then subjected to one or more CC coupling reaction(s) in the presence of hydrogen, and in the presence of a catalyst system having both hydrogenation activity and CC coupling activity.

A method for the catalytic conversion of ketoacids, including methods for increasing the molecular weight of ketoacids, the method comprising the steps of providing in a reactor a feedstock comprising at least one ketoacid. The feedstock is then subjected to one or more CC coupling reaction(s) in the presence of hydrogen, and in the presence of a catalyst system having both hydrogenation activity and CC coupling activity.

A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula:

R.sup.1C(O)(CR.sup.2.sub.2)(OR.sup.3).sub.p(CR.sup.4.sub.2).sub.q-L-A

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, p, q, A and L are as defined herein.

A sulfonic acid or carboxylic acid containing a carbonyl group, or a salt thereof represented by the following formula:

R.sup.1C(O)(CR.sup.2.sub.2)(OR.sup.3).sub.p(CR.sup.4.sub.2).sub.q-L-A

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, p, q, A and L are as defined herein.

Catalytic conversion of ketoacids is disclosed, including methods for increasing the molecular weight of ketoacids. An exemlary method includes providing in a reactor a feedstock having at least one ketoacid. The feedstock is then subjected to one or more CC-coupling reaction(s) in the presence of a catalyst system having a first metal oxide and a second metal oxide.

Catalytic conversion of ketoacids is disclosed, including methods for increasing the molecular weight of ketoacids. An exemlary method includes providing in a reactor a feedstock having at least one ketoacid. The feedstock is then subjected to one or more CC-coupling reaction(s) in the presence of a catalyst system having a first metal oxide and a second metal oxide.

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

##STR00001##

A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

##STR00001##

The description relates to, inter alia, recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include methylenemalonic acid and intermediates, as well as their salts and esters.

The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction. The method comprises the following steps: centrifuging the microbial fermentation broth or enzymatic conversion solution containing -KG and PA to remove the cells and other visible solids; removing the macromolecular impurities by ultrafiltration; evaporating and concentrating under reduced pressure conditions; extracting with the water-insoluble extraction after acidification; separating crude crystals of -KG and crude liquid of PA by evaporation crystallization method (if concentration of PA is great higher than that of -KG, crystallization separation should be conducted after distilling partial pure pyruvate); washing the crude crystal of -KG with water-insoluble organic solvent as ethyl acetate or butyl acetate, drying and crushing to obtain qualified -KG; distilling to gain qualified PA product applying high vacuum distillation (or molecular distillation).