The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.

The present disclosure provides compositions and methods for metathesizing a first alkenyl or alkynyl group with a second alkenyl or alkynyl group, the composition comprising a ruthenium metathesis catalyst and a photoredox catalyst that is activated by visible light.

The present invention provides, in part a novel class of nonoate compounds which exhibit nitric oxide releasing activity and their pharmaceutically acceptable salts, esters and prodrugs. The compounds release nitric oxide upon activation by contact with plasma. The present invention also relates to the use of the disclosed compounds to deliver nitric oxide to treat disorders arising from nitric oxide dysregulation.

The present disclosure addresses the problem of providing a novel method for producing a fluorinated iodinated organic compound.

The problem can be solved by a method for producing a fluorinated iodinated organic compound, comprising reacting a compound represented by formula (1):

##STR00001##

wherein R.sup.1 and R.sup.2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R.sup.1 and R.sup.2 optionally form a ring together with the two adjacent carbon atoms; and n is 1 or 2, with a fluorine source, an iodine source, and an oxidizing agent or radical generator to add fluorine and iodine to the double bond or triple bond.

The present disclosure addresses the problem of providing a novel method for producing a fluorinated iodinated organic compound.

The problem can be solved by a method for producing a fluorinated iodinated organic compound, comprising reacting a compound represented by formula (1):

##STR00001##

wherein R.sup.1 and R.sup.2 are each independently a hydrogen atom, a halogen atom, or an organic group, or R.sup.1 and R.sup.2 optionally form a ring together with the two adjacent carbon atoms; and n is 1 or 2, with a fluorine source, an iodine source, and an oxidizing agent or radical generator to add fluorine and iodine to the double bond or triple bond.

The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

The present invention relates to modulators of lipoxygenase and/or cyclooxygenase enzyme. The present invention also provides compositions comprising such modulators, and methods therewith for treating lipoxygenase receptor mediated diseases.

The present invention provides, in part a novel class of nonoate compounds which exhibit nitric oxide releasing activity and their pharmaceutically acceptable salts, esters and prodrugs. The compounds release nitric oxide upon activation by contact with plasma. The present invention also relates to the use of the disclosed compounds to deliver nitric oxide to treat disorders arising from nitric oxide dysregulation.

A compound of formula (I) ##STR00001## for use in electrolyte compositions for electrochemical cells, wherein R.sup.1 and R.sup.2 are selected independently from each other from H, F, CN, R′, OR′, OC(O)R′, and OP(O)R″.sub.2, R.sup.3 is selected from H, C.sub.1 to C.sub.12 alkyl, C.sub.3 to C.sub.6 (hetero)cycloalkyl, C.sub.2 to C.sub.12 alkenyl, C.sub.2 to C.sub.12 alkynyl, C.sub.5 to C.sub.12 (hetero)aryl, and C.sub.6 to C.sub.24 (hetero)aralkyl, R.sup.4 is selected from C.sub.1 to C.sub.12 alkyl, C.sub.3 to C.sub.6 (hetero)cycloalkyl, C.sub.2 to C.sub.12 alkenyl, C.sub.2 to C.sub.12 alkynyl, C.sub.5 to C.sub.12 (hetero)aryl, and C.sub.6 to C.sub.24 (hetero)aralkyl, or R.sup.3 and R.sup.4 are bound together and form together with the group —C—C(O)—O— a 5- to 6-membered heterocycle which may be substituted by one or more substituents selected from F and optionally fluorinated C.sub.1 to C.sub.12 alkyl.

A compound of formula (I) ##STR00001## for use in electrolyte compositions for electrochemical cells, wherein R.sup.1 and R.sup.2 are selected independently from each other from H, F, CN, R′, OR′, OC(O)R′, and OP(O)R″.sub.2, R.sup.3 is selected from H, C.sub.1 to C.sub.12 alkyl, C.sub.3 to C.sub.6 (hetero)cycloalkyl, C.sub.2 to C.sub.12 alkenyl, C.sub.2 to C.sub.12 alkynyl, C.sub.5 to C.sub.12 (hetero)aryl, and C.sub.6 to C.sub.24 (hetero)aralkyl, R.sup.4 is selected from C.sub.1 to C.sub.12 alkyl, C.sub.3 to C.sub.6 (hetero)cycloalkyl, C.sub.2 to C.sub.12 alkenyl, C.sub.2 to C.sub.12 alkynyl, C.sub.5 to C.sub.12 (hetero)aryl, and C.sub.6 to C.sub.24 (hetero)aralkyl, or R.sup.3 and R.sup.4 are bound together and form together with the group —C—C(O)—O— a 5- to 6-membered heterocycle which may be substituted by one or more substituents selected from F and optionally fluorinated C.sub.1 to C.sub.12 alkyl.