The present invention concerns new halogen substituted diketone compounds, new pyrazole compounds, processes for the manufacture of pyrazole compounds and processes for the manufacture of agrochemical or pharmaceutical compounds.

Disclosed are processes for the manufacture of pyrazole compounds of formula (I) and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically active compounds, wherein in the processes, at least two steps are conducted in the presence of at least one solvent which is the same in the at least two steps, wherein the at least one same solvent is selected from the group consisting of aromatic hydrocarbons, alkanes, carboxylic acid esters, ethers, nitriles and dimethylformamide.

##STR00001##

Disclosed are processes for the manufacture of pyrazole compounds of formula (I) and their application in the manufacture of pyrazole derivatives, in particular in processes for the manufacture of pharmaceutically or agrochemically active compounds, wherein in the processes, at least two steps are conducted in the presence of at least one solvent which is the same in the at least two steps, wherein the at least one same solvent is selected from the group consisting of aromatic hydrocarbons, alkanes, carboxylic acid esters, ethers, nitriles and dimethylformamide.

##STR00001##

Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesis that enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers.

Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesis that enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers.

A method for preparing an enone compound of formula (I) is disclosed. Furthermore, the enone compound of formula (I) obtained by the method may be used alone, or in combination with a washing agent, a cleaning agent, an insect repellant agent, a pharmaceutical agent, a fragrance, a pro-fragrance, or combinations thereof.

A method for preparing an enone compound of formula (I) is disclosed. Furthermore, the enone compound of formula (I) obtained by the method may be used alone, or in combination with a washing agent, a cleaning agent, an insect repellant agent, a pharmaceutical agent, a fragrance, a pro-fragrance, or combinations thereof.

Provided is an efficient and economical production method of a nitrogen-containing compound. A method for producing a compound represented by the formula R.sup.3C(O)CHCHNR.sup.1R.sup.2, including reacting a compound represented by the following formula (4) with more than 6-fold moles of a compound represented by the formula NR.sup.1R.sup.2C(O)H to give a reaction mixture of the compound represented by the formula (4) and the compound represented by the formula NR.sup.1R.sup.2C(O)H, and reacting the reaction mixture with a compound represented by the formula R.sup.3C(O)CH.sub.3 by using a basic compound:

##STR00001##

wherein X is a halogen atom and R.sup.1, R.sup.2 and R.sup.3 are each independently an alkyl group having 1-6 carbon atoms.

Provided is an efficient and economical production method of a nitrogen-containing compound. A method for producing a compound represented by the formula R.sup.3C(O)CHCHNR.sup.1R.sup.2, including reacting a compound represented by the following formula (4) with more than 6-fold moles of a compound represented by the formula NR.sup.1R.sup.2C(O)H to give a reaction mixture of the compound represented by the formula (4) and the compound represented by the formula NR.sup.1R.sup.2C(O)H, and reacting the reaction mixture with a compound represented by the formula R.sup.3C(O)CH.sub.3 by using a basic compound:

##STR00001##

wherein X is a halogen atom and R.sup.1, R.sup.2 and R.sup.3 are each independently an alkyl group having 1-6 carbon atoms.

A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.