The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.

Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.

The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure:

##STR00001## wherein A, B, W, Y, Z, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.q and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.

The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure:

##STR00001## wherein A, B, W, Y, Z, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.q and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.

An amide derivative represented by the following Formula (1) is provided as an amide derivative showing a significantly excellent effect for a pest control action. In the following Formula (1), A represents a carbon atom, a nitrogen atom, or the like, and K represents a non-metal atomic group necessary for forming a cyclic linking group derived from benzene or a heterocyclic. X represents a halogen atom or the like; n represents an integer of from 0 to 4. R.sub.1 and R.sub.2 represent hydrogen atoms, alkyl groups, or the like. T represents —C(=G.sub.1)-Q.sub.1 or —C(=G.sub.1)-G.sub.2Q.sub.2, and G.sub.1 to G.sub.3 each represent oxygen atoms or the like. Q.sub.1 and Q.sub.2 each represent a hydrogen atom, an alkyl group, an aryl group, or the like. Y.sub.1 and Y.sub.5 each represent a halogen atom or the like, Y.sub.2 and Y.sub.4 each represent a hydrogen atom or the like, and Y.sub.3 represents a C2-C5 haloalkyl group. ##STR00001##

An amide derivative represented by the following Formula (1) is provided as an amide derivative showing a significantly excellent effect for a pest control action. In the following Formula (1), A represents a carbon atom, a nitrogen atom, or the like, and K represents a non-metal atomic group necessary for forming a cyclic linking group derived from benzene or a heterocyclic. X represents a halogen atom or the like; n represents an integer of from 0 to 4. R.sub.1 and R.sub.2 represent hydrogen atoms, alkyl groups, or the like. T represents —C(=G.sub.1)-Q.sub.1 or —C(=G.sub.1)-G.sub.2Q.sub.2, and G.sub.1 to G.sub.3 each represent oxygen atoms or the like. Q.sub.1 and Q.sub.2 each represent a hydrogen atom, an alkyl group, an aryl group, or the like. Y.sub.1 and Y.sub.5 each represent a halogen atom or the like, Y.sub.2 and Y.sub.4 each represent a hydrogen atom or the like, and Y.sub.3 represents a C2-C5 haloalkyl group. ##STR00001##

The present invention includes a multi-layer 3D material, a method of making, and a catalyst comprising: a first, a second, and a third layer, wherein each of the layers are arranged in a nearly parallel fashion with chirality along a center plane.

The present invention includes a multi-layer 3D material, a method of making, and a catalyst comprising: a first, a second, and a third layer, wherein each of the layers are arranged in a nearly parallel fashion with chirality along a center plane.