Patent classifications
C07C237/44
NOVEL CYSTOBACTAMIDES
The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
##STR00001##
NOVEL CYSTOBACTAMIDES
The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
##STR00001##
Processes and intermediates for making sweet taste enhancers
The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): ##STR00001##
wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
Processes and intermediates for making sweet taste enhancers
The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): ##STR00001##
wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS
A TLR-independent adjuvant compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable salt is disclosed in
##STR00001##
which X, Y, Z, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and W are defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.
TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS
A TLR-independent adjuvant compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable salt is disclosed in
##STR00001##
which X, Y, Z, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and W are defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.
Insecticidal compounds
The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests; wherein R.sup.1, R.sup.2, G.sup.1, G.sup.2, Q.sup.1 and Q.sup.2 are as defined in claim 1; or salts thereof. ##STR00001##
BCL-3 INHIBITORS
The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure:
##STR00001## wherein A, B, W, Y, Z, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.q and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.
BCL-3 INHIBITORS
The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure:
##STR00001## wherein A, B, W, Y, Z, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.q and q are as defined herein. The compounds can be used as inhibitors of Bcl-3 and can be used for the treatment of cancer, particularly metastatic cancer.
Uses of histone acetyltransferase activators
The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.