The present invention involves preparing compounds represented by the following formula:

##STR00001##

from a compound of the following formula:

##STR00002##

In these formulae: R.sup.1 represents a Br group, an iodine group, a Cl group, an NO.sub.2 group, or an NH.sub.2 group; R.sup.2 represents a halogen group, an NO.sub.2 group, an NH.sub.2 group, Sn(R.sup.6).sub.3, N═N—NR.sup.7R.sup.8, OSO.sub.2R.sup.9, N R.sup.10R.sup.11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R.sup.30 represents a protective group PG.sup.1; R.sup.40 or R.sup.50 represent hydrogen, a protective group PG.sup.2, or C.sub.6H.sub.5(C.sub.6H.sub.5)C═N, in which NR.sup.40R.sup.50 are together.

Hydroxyaldimines of formula (I), their reaction products, in particular products of their reaction with polyisocyanates, and compositions including isocyanate groups and containing such reaction products. The hydroxyaldimine permits compositions which have good storage stability, a long open time, low odour, rapid, bubble-free curing and good mechanical properties, and which are not susceptible to plasticizer migration and have a particularly low content of monomeric diisocyanates. In particular, it permits reactive hot-melt adhesives with a particularly good workability.

Hydroxyaldimines of formula (I), their reaction products, in particular products of their reaction with polyisocyanates, and compositions including isocyanate groups and containing such reaction products. The hydroxyaldimine permits compositions which have good storage stability, a long open time, low odour, rapid, bubble-free curing and good mechanical properties, and which are not susceptible to plasticizer migration and have a particularly low content of monomeric diisocyanates. In particular, it permits reactive hot-melt adhesives with a particularly good workability.

The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as, for example, ricin, and of viruses that use the internalization pathway for infecting cells.

Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

Disclosed is a fluorescent compound for the detection of isocyanate substances, a preparation method therefor and use thereof as a test-paper-type detection probe. The fluorescent compound is 2,4-di(((4′-(diphenylamino)-[1,1′-biphenyl]-4-yl)imino)methyl)phenol. The fluorescent compound is prepared by means of a one-step method. The fluorescent compound has simple and convenient preparation with high yield, and is capable of making a rapid and specific response to isocyanate substances. Moreover, the fluorescence intensity of the fluorescent compound will enhance with the increase of the isocyanate concentration. The fluorescent compound can be made into a portable test-paper-type probe for the detection of isocyanate substances in air, and can achieve the visual detection of volatile isocyanate gases. The probe has an aggregation-induced emission effect, and thus it has higher fluorescence quantum yield when using a test-paper-type probe for detection.

Disclosed is a fluorescent compound for the detection of isocyanate substances, a preparation method therefor and use thereof as a test-paper-type detection probe. The fluorescent compound is 2,4-di(((4′-(diphenylamino)-[1,1′-biphenyl]-4-yl)imino)methyl)phenol. The fluorescent compound is prepared by means of a one-step method. The fluorescent compound has simple and convenient preparation with high yield, and is capable of making a rapid and specific response to isocyanate substances. Moreover, the fluorescence intensity of the fluorescent compound will enhance with the increase of the isocyanate concentration. The fluorescent compound can be made into a portable test-paper-type probe for the detection of isocyanate substances in air, and can achieve the visual detection of volatile isocyanate gases. The probe has an aggregation-induced emission effect, and thus it has higher fluorescence quantum yield when using a test-paper-type probe for detection.

This disclosure provides compositions of SALTAME core containing compounds and associated methods for use in tracking cells by magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and related methods.