Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hydrazone compounds.

Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hydrazone compounds.

A carbazate-functional compound includes a plurality of groups having the following structure: [formula (I)] where X forms at least a portion of: a urethane linkage, an ester linkage, or an ether linkage. At least one R.sub.1 from the plurality of groups is free of a hydroxyl-functional group.

##STR00001##

A carbazate-functional compound includes a plurality of groups having the following structure: [formula (I)] where X forms at least a portion of: a urethane linkage, an ester linkage, or an ether linkage. At least one R.sub.1 from the plurality of groups is free of a hydroxyl-functional group.

##STR00001##