Described herein are methods of oxidative coupling of aryl boron reagents with sp.sup.3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Described herein are methods of oxidative coupling of aryl boron reagents with sp.sup.3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Monomeric and oligomeric compounds of Formula (I) comprising hydrophobic alkyl or alkenyl ester moieties and hydrophilic carboxylate moieties: ##STR00001##
wherein R.sup.1 is C.sub.1-C.sub.6 alkyl, R.sup.2 is C.sub.l0-C.sub.30 alkyl or C.sub.8-C.sub.30 alkenyl, Y is a cation, Z is a sulfur-containing moiety, and n and k are integers as defined herein. The compounds of Formula (I) have surfactant properties. Also provided are compositions comprising the compounds of Formula (I), and methods of using the compounds or compositions for cleaning purposes.

Monomeric and oligomeric compounds of Formula (I) comprising hydrophobic alkyl or alkenyl ester moieties and hydrophilic carboxylate moieties: ##STR00001##
wherein R.sup.1 is C.sub.1-C.sub.6 alkyl, R.sup.2 is C.sub.l0-C.sub.30 alkyl or C.sub.8-C.sub.30 alkenyl, Y is a cation, Z is a sulfur-containing moiety, and n and k are integers as defined herein. The compounds of Formula (I) have surfactant properties. Also provided are compositions comprising the compounds of Formula (I), and methods of using the compounds or compositions for cleaning purposes.

Monomeric and oligomeric compounds of Formula (I) comprising hydrophobic alkyl or alkenyl ester moieties and hydrophilic carboxylate moieties: ##STR00001##
wherein R.sup.1 is C.sub.1-C.sub.6 alkyl, R.sup.2 is C.sub.l0-C.sub.30 alkyl or C.sub.8-C.sub.30 alkenyl, Y is a cation, Z is a sulfur-containing moiety, and n and k are integers as defined herein. The compounds of Formula (I) have surfactant properties. Also provided are compositions comprising the compounds of Formula (I), and methods of using the compounds or compositions for cleaning purposes.

In crop production in the fields of agriculture, horticulture and the like, the damage caused by diseases etc. is still immense, and diseases resistant to existing microbicides have emerged. Under such circumstances, the development of novel agricultural and horticultural microbicides is desired. The present invention provides an anthranilic acid ester compound represented by the general formula (1): ##STR00001## (wherein A.sup.1, A.sup.3 and A.sup.4 each represent a CH group, A.sup.2 represents a C-haloalkyl group, R.sup.1 represents an alkyl group, R.sup.3 represents a hydrogen atom or an acyl group, R.sup.4, R.sup.5 and R.sup.7 each represent a hydrogen atom, R.sup.6 represents a haloalkyl group, Z represents an alkyl group, and m represents 0, 1 or 2), or a salt thereof, an agricultural and horticultural microbicide comprising the compound or a salt thereof as an active ingredient, and a method for using the microbicide.

In crop production in the fields of agriculture, horticulture and the like, the damage caused by diseases etc. is still immense, and diseases resistant to existing microbicides have emerged. Under such circumstances, the development of novel agricultural and horticultural microbicides is desired. The present invention provides an anthranilic acid ester compound represented by the general formula (1): ##STR00001## (wherein A.sup.1, A.sup.3 and A.sup.4 each represent a CH group, A.sup.2 represents a C-haloalkyl group, R.sup.1 represents an alkyl group, R.sup.3 represents a hydrogen atom or an acyl group, R.sup.4, R.sup.5 and R.sup.7 each represent a hydrogen atom, R.sup.6 represents a haloalkyl group, Z represents an alkyl group, and m represents 0, 1 or 2), or a salt thereof, an agricultural and horticultural microbicide comprising the compound or a salt thereof as an active ingredient, and a method for using the microbicide.

The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.

The present disclosure relates to HIF-2? inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2? scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.

The present application relates to compounds according to (Formula IA) or (Formula IB):

##STR00001## or a pharmaceutically acceptable salt thereof.

The compounds can be used as inhibitors of ROR and are useful for the treatment of ROR mediated diseases.