A system and method for use in synthesis and promoting interactions of chiral molecules. The system can include: a container configured for containing fluid mixture comprising one or more reactant molecules and at least one surface comprising ferromagnetic or paramagnetic material located to be in at least partial contact with reactants in said container. The ferromagnetic of paramagnetic material can be magnetizable with magnetization direction perpendicular to said at least one surface, thereby providing chiral selective synthesis from said one or more reactant molecules. The technique can enable selective interactions of enantiomers of selected handedness of chiral molecules or formation of selected enantiomers from achiral molecule reactants.

A system and method for use in synthesis and promoting interactions of chiral molecules. The system can include: a container configured for containing fluid mixture comprising one or more reactant molecules and at least one surface comprising ferromagnetic or paramagnetic material located to be in at least partial contact with reactants in said container. The ferromagnetic of paramagnetic material can be magnetizable with magnetization direction perpendicular to said at least one surface, thereby providing chiral selective synthesis from said one or more reactant molecules. The technique can enable selective interactions of enantiomers of selected handedness of chiral molecules or formation of selected enantiomers from achiral molecule reactants.

An object of the present invention is to provide a method for manufacturing methionine capable of achieving an improvement in ammonia removal efficiency. The manufacturing method of the present invention comprises a removal step of supplying a liquid containing a methionine salt, which is obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin and then hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin, to a diffusion tower from an upper portion thereof while supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, and the stripping gas contains a process gas generated in a process of manufacturing methionine.

An object of the present invention is to provide a method for manufacturing methionine capable of achieving an improvement in ammonia removal efficiency. The manufacturing method of the present invention comprises a removal step of supplying a liquid containing a methionine salt, which is obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin and then hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin, to a diffusion tower from an upper portion thereof while supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, and the stripping gas contains a process gas generated in a process of manufacturing methionine.

An object of the present invention is to provide a method for manufacturing methionine capable of achieving an improvement in ammonia removal efficiency. The manufacturing method of the present invention comprises a removal step of supplying a liquid containing a methionine salt, which is obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, or a compound obtained by reacting 3-methylmercaptopropionaldehyde and hydrocyanic acid, with carbon dioxide and ammonia to obtain a liquid containing 5-(2-methylmercaptoethyl)hydantoin and then hydrolyzing the 5-(2-methylmercaptoethyl)hydantoin, to a diffusion tower from an upper portion thereof while supplying a stripping gas to the diffusion tower from a lower portion thereof to remove ammonia contained in the liquid through stripping, and the stripping gas contains a process gas generated in a process of manufacturing methionine.

A process of making N,N′-diacetyl-L-Cystine disodium salt, the process comprising: (i) Mixing hydroxy alkane (between 0.5-100 L, preferably between 0.5-10 L, more preferably between 1-3 L, most preferably 1 L per mol of cystine) with a sodium base (4.0 molar equivalents per mole of cystine) to form a cold solution at a temperature of from 5 to 10° C.; (ii) Adding cystine (1 molar equivalent) to said cold solution and stirring, for a sufficient time, to form a basic cystine solution; (iii) Optionally, Cooling the cystine solution to 5° C.; (iv) Adding acetyl chloride (2 molar equivalents per mole of cystine) portionwise, while maintaining the temperature between 3 and 50° C., preferably between 5 and 35° C., more preferably below 10° C., most preferably 5° C., thereby resulting in a white suspension; (v) Stirring said white suspension and allowing said suspension to warm up to a room temperature of 15° C. to 50° C., preferably 20° C. to 35° C., more preferably 20° C., thereby resulting in N,N′-diacetyl-L-Cystine disodium salt product dissolved in solution and sodium chloride by-product precipitated solid in said suspension. The present description discloses an exemplary process on a small laboratory scale (500 mg cystine educt; 688 mg product; 90% yield) (page 16; example 1).

A process of making N,N′-diacetyl-L-Cystine disodium salt, the process comprising: (i) Mixing hydroxy alkane (between 0.5-100 L, preferably between 0.5-10 L, more preferably between 1-3 L, most preferably 1 L per mol of cystine) with a sodium base (4.0 molar equivalents per mole of cystine) to form a cold solution at a temperature of from 5 to 10° C.; (ii) Adding cystine (1 molar equivalent) to said cold solution and stirring, for a sufficient time, to form a basic cystine solution; (iii) Optionally, Cooling the cystine solution to 5° C.; (iv) Adding acetyl chloride (2 molar equivalents per mole of cystine) portionwise, while maintaining the temperature between 3 and 50° C., preferably between 5 and 35° C., more preferably below 10° C., most preferably 5° C., thereby resulting in a white suspension; (v) Stirring said white suspension and allowing said suspension to warm up to a room temperature of 15° C. to 50° C., preferably 20° C. to 35° C., more preferably 20° C., thereby resulting in N,N′-diacetyl-L-Cystine disodium salt product dissolved in solution and sodium chloride by-product precipitated solid in said suspension. The present description discloses an exemplary process on a small laboratory scale (500 mg cystine educt; 688 mg product; 90% yield) (page 16; example 1).

A process of making N,N′-diacetyl-L-Cystine disodium salt, the process comprising: (i) Mixing hydroxy alkane (between 0.5-100 L, preferably between 0.5-10 L, more preferably between 1-3 L, most preferably 1 L per mol of cystine) with a sodium base (4.0 molar equivalents per mole of cystine) to form a cold solution at a temperature of from 5 to 10° C.; (ii) Adding cystine (1 molar equivalent) to said cold solution and stirring, for a sufficient time, to form a basic cystine solution; (iii) Optionally, Cooling the cystine solution to 5° C.; (iv) Adding acetyl chloride (2 molar equivalents per mole of cystine) portionwise, while maintaining the temperature between 3 and 50° C., preferably between 5 and 35° C., more preferably below 10° C., most preferably 5° C., thereby resulting in a white suspension; (v) Stirring said white suspension and allowing said suspension to warm up to a room temperature of 15° C. to 50° C., preferably 20° C. to 35° C., more preferably 20° C., thereby resulting in N,N′-diacetyl-L-Cystine disodium salt product dissolved in solution and sodium chloride by-product precipitated solid in said suspension. The present description discloses an exemplary process on a small laboratory scale (500 mg cystine educt; 688 mg product; 90% yield) (page 16; example 1).

An object of the present invention to provide a method for producing methionine with consideration given to the environment. The production method of the present invention comprises a removal step of blowing an inert gas into a liquid containing 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia, and a recovery step of bringing the emission gas into contact with a washing liquid to recover ammonia contained in the emission gas.

An object of the present invention to provide a method for producing methionine with consideration given to the environment. The production method of the present invention comprises a removal step of blowing an inert gas into a liquid containing 5-(2-methylmercaptoethyl)hydantoin and thereby diffusing ammonia remaining in the liquid to obtain an emission gas containing the ammonia, and a recovery step of bringing the emission gas into contact with a washing liquid to recover ammonia contained in the emission gas.