C07C333/04

Ionizable cationic lipid for RNA delivery

What is described is a compound of formula I ##STR00001##
consisting of a compound in which R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons; R.sub.2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L.sub.1 and L.sub.2 are the same or different, each a linear alkylene or alkenylene consisting of 2 to 20 carbons; X.sub.1 is S or O; R.sub.3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R.sub.4 and R.sub.5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

CARBAMOYL PHENYLALANINOL ANALOGS AND USES THEREOF
20210093603 · 2021-04-01 ·

The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.

CARBAMOYL PHENYLALANINOL ANALOGS AND USES THEREOF
20210093603 · 2021-04-01 ·

The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.

Carbondisulfide derived zwitterions
10975027 · 2021-04-13 ·

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Carbondisulfide derived zwitterions
10975027 · 2021-04-13 ·

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Ionizable cationic lipid for RNA delivery

Disclosed herein is a compound of Formula I, wherein R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons; R.sub.2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons; L.sub.1 and L.sub.2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons; X.sub.1 is S or O; R.sub.3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R.sub.4 and R.sub.5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt or solvate thereof. ##STR00001##

Ionizable cationic lipid for RNA delivery

Disclosed herein is a compound of Formula I, wherein R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons; R.sub.2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons; L.sub.1 and L.sub.2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons; X.sub.1 is S or O; R.sub.3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R.sub.4 and R.sub.5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt or solvate thereof. ##STR00001##

ULTRA LOW RANGE CHLORINE MEASUREMENT
20210025862 · 2021-01-28 ·

An embodiment provides a method for measuring total chlorine in a solution, including: preparing a thiocarbamate indicator; introducing the thiocarbamate indicator to a solution, wherein the solution contains an amount of monochloramine; adding an additive to the solution, wherein the additive accelerates the reaction rate between the thiocarbamate indicator and monochloramine and causes a change in fluorescence of the solution; and measuring the amount of monochloramine in the solution by measuring an intensity of the fluorescence. Other aspects are described and claimed.

METHOD OF SYNTHESIS OF AN IONIZABLE CATIONIC LIPID
20210002217 · 2021-01-07 ·

What is described is a method of synthesis of the compound of formula 1A,

##STR00001## or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R.sub.4 and R.sub.5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L.sub.3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.

METHOD OF SYNTHESIS OF AN IONIZABLE CATIONIC LIPID
20210002217 · 2021-01-07 ·

What is described is a method of synthesis of the compound of formula 1A,

##STR00001## or a salt thereof, wherein R.sub.3 is a linear or branched alkene of 1, 2, 3, 4, 5 or 6 carbons; R.sub.4 and R.sub.5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; and L.sub.3 is a bond or an alkane of 1, 2, 3, 4, 5 or 6 carbons.