The present disclosure relates to using green solvents to synthesize an array of imines, imine-related and imine-derived compounds in an efficient and eco-friendly matter, satisfying green chemistry requirements. Reaction embodiments are performed using solvents, such as ethyl lactate and dimethyl isosorbide, which are both individually characterized as green. In embodiments, solvents include lactic whey and/or water as co-solvents. In these green solvents, the synthesis process discussed herein can produce up to quantitative yields of product at room temperature in a short duration. Embodiments include a method of forming an imine, imine-related or imine-derived compound product. In embodiments, the methods include mixing an aldehyde reactant with a nucleophilic/nitrogen-containing reactant in a green solvent at a temperature between negative twenty degrees Celsius (−20° C.) and positive fifty degrees Celsius (50° C.); stirring the mixture; and forming an imine, imine-related or imine-derived compound product.

The present invention relates to aromatic isothiocyanates of formula U

##STR00001##

as defined in claim 1, to liquid-crystalline media comprising one or more compounds of formula U and to high-frequency components comprising these media, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves, tunable filters, tunable metamaterial structures, and electronic beam steering antennas, e.g. phased array antennas.

The present invention relates to a cannabidiol (CBD) type cannabinoid compound for use as a medicament. The CBD-type cannabinoid, cannabidiol-C6 (CBD-C6), is a naturally occurring cannabinoid that can be found in minor quantities in the cannabis plant. Furthermore, the cannabinoid can be produced by synthetic means and a method for the production of CBD-C6 is described herein. In addition, disclosed herein are data which demonstrate the efficacy of CBD-C6 in models of disease.

The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.

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The present disclosure describes terpenophenolic compounds and their use in medicine. The present disclosure further describes perrottetinene-like compounds, the manufacture thereof, formulations containing same and their use in medicine. Such compounds include (1′R, 2′R)-5′-methyl-phenethyl-2′-(prop-1-ene-2-yl)-1′, 2′, 3, 4′-tetrahydro-[1, 1-biphenyl]-2,6-diol (CBD-PET) or (1′R,2′R)-4-(4-hydroxyphenethyl)-5′-methyl-2′-(prop-1-ene-2-yl)-1′, 2′, 3, 4′-tetrahydro-[1, 1′-biphenyl]-2,6-diol (CBD-PET-OH).

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

##STR00001##

A method for extraction, in which an extraction agent is used for dissolving at least one extraction material out of a substance. The extraction agent includes fatty acid ethyl ester and/or fatty acid methyl ester. In one embodiment the extraction agent is an omega-3 and/or omega-6 fatty acid, preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. In one embodiment the extraction agent includes at least 500 mg/g, preferably at least 700 mg/g of the fatty acid ethyl ester and/or of the fatty acid methyl ester. Expediently, the mixture of substances is a plant material, preferably hemp, and the extraction material is a cannabinoid, preferably CBD and/or THC.

Disclosed is an industrial extraction method of cannabidiol, pertaining to the field of medicine and chemical industry. The present invention aims to resolve the problems of difficulty in wax removal, low extraction rate of cannabidiol, and excessively high content of tetrahydrocannabinol during extraction using conventional solvents in the prior art. The extraction method employs raw material pretreatment, granulation, extraction, liquid-liquid extraction, decolorization, concentration, and other processes, such that wax removal from an extracted liquid is improved, the purity of a crude cannabidiol oil can be increased to 60%, and 40% of tetrahydrocannabinol can be removed. The method has high extraction yields and low costs, and can be implemented in large-scale industrial production.

The present invention relates to methods for treating cannabis biomass in order to isolate tetrahydrocannabinolic acid (THCA). In another aspect, the present invention relates to a process that involves purification followed by extraction of cannabis biomass to isolate and improve yields of high-purity crystalline extracts.

The present invention relates to compounds of formula (I) as herein defined, capable of releasing fragrant compounds in a controlled manner into the surroundings. The present invention is also concerned with a process for their production, and consumer products comprising them.