The invention relates to heterocyclic sulfonamide derivatives and their use in the treatment and prophylaxis of autoimmune, inflammatory, cardiovascular, neuronal, auditory, renal and metabolic mediated diseases, and to compositions containing said derivatives and processes for their preparation.

The present invention provides compounds for inhibiting matriptase 2, or a mutant thereof, and compositions and methods of use thereof.

The present invention provides compounds for inhibiting matriptase 2, or a mutant thereof, and compositions and methods of use thereof.

Disclosed herein are compounds of the formulas: (I) as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions of these compounds. In some aspects, the compounds and compositions provided herein may be used to degrade Mdm2. Also provided are methods of administering compounds and compostions provided herein to a patient in need thereof, for example, for the treatment of cancers.

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