Provided are a fruquintinib and a saccharin salt or eutectic crystal, a fruquintinib and a malonic acid eutectic crystal or a fruquintinib and a maleic eutectic crystal, a preparation method therefor, a pharmaceutical composition containing thereof, and uses thereof in preparing drugs for treating and/or preventing diseases related to abnormal angiogenesis, such as cancer, tumors, macular degeneration, chronic inflammation and the like.

Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition containing the compound can be used to treat IDH1 mutation-induced cancers. ##STR00001##

The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).

The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).

A compound represented by Formula (1):

##STR00001##

The compound can be used as insecticides.

A compound represented by Formula (1):

##STR00001##

The compound can be used as insecticides.

The present invention relates to the novel use of an isothiazolecarboxamide of the formula (I)

##STR00001## (common name: Isotianil) for controlling “Candidatus” Liberibacter spp and/or “Candidatus” Phytoplasma spp, preferably, “Candidatus” Liberibacter solanacearum and/or “Candidatus” Phytoplasma americanum, more preferred “Candidatus” Liberibacter solanacearum, in plants of the Solanaceae family, preferably in potatoes.

The present invention relates to the novel use of an isothiazolecarboxamide of the formula (I)

##STR00001## (common name: Isotianil) for controlling “Candidatus” Liberibacter spp and/or “Candidatus” Phytoplasma spp, preferably, “Candidatus” Liberibacter solanacearum and/or “Candidatus” Phytoplasma americanum, more preferred “Candidatus” Liberibacter solanacearum, in plants of the Solanaceae family, preferably in potatoes.

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such a SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

##STR00001##

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such a SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

##STR00001##