This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

A compound represented by Formula (1): ##STR00001## The compound can be used as insecticides.

A compound represented by Formula (1): ##STR00001## The compound can be used as insecticides.

The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

An aqueous composition comprising: (a) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (b) an aromatic acid anhydride comprising from 6 to 30 carbon atoms.

An aqueous composition comprising: (a) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (b) an aromatic acid anhydride comprising from 6 to 30 carbon atoms.