Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

The invention relates to the field of pesticide technology, and in particular a type of substituted thiadiazinone dioxide, preparation method, herbicidal composition and application thereof. The substituted thiadiazinone dioxide, as shown in general formula I.

##STR00001## wherein, R.sub.1 and R.sub.2 each independently represent hydrogen, cyano or alkyl with or without halogen and so on; X represents hydrogen or halogen; Y represents C—Z or N; Z represents hydrogen or halogen; and when X represents halogen, Z represents hydrogen. The compound has excellent herbicidal activity against gramineous weeds, broadleaf weeds or amaranthaceous weeds, and has high selectivity for crops such as soybean, corn, rice or wheat.

The invention relates to the field of pesticide technology, and in particular a type of substituted thiadiazinone dioxide, preparation method, herbicidal composition and application thereof. The substituted thiadiazinone dioxide, as shown in general formula I.

##STR00001## wherein, R.sub.1 and R.sub.2 each independently represent hydrogen, cyano or alkyl with or without halogen and so on; X represents hydrogen or halogen; Y represents C—Z or N; Z represents hydrogen or halogen; and when X represents halogen, Z represents hydrogen. The compound has excellent herbicidal activity against gramineous weeds, broadleaf weeds or amaranthaceous weeds, and has high selectivity for crops such as soybean, corn, rice or wheat.

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

The invention relates to thiadiazine derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of α7 nicotinic acetylcholine receptor activity in a mammalian subject Formula (I):

##STR00001##

The invention relates to thiadiazine derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of α7 nicotinic acetylcholine receptor activity in a mammalian subject Formula (I):

##STR00001##

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.