The present document is directed to co-crystals of resveratrol and/or curcumin with piperazine and their use in medicine and/or as food and feed supplements.

A curing agent or a curing accelerator which is easy to synthesize and may cure an epoxy resin and the like, or may accelerate the curing is provided. A curing agent or a curing accelerator according to some embodiments of the present invention has a highly-coordinated silicon structure.

A process for the depletion of 2-methoxyethanol (MOE) from a mixture comprising predominantly morpholine (MO) (crude morpholine), wherein crude morpholine is distilled in a distillation column in the presence of an alkali metal compound of the general formula M.sup.+[RO.sup.] (M.sup.+ is alkali metal cation and R is hydrogen (H), methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl), where MO and a compound of the general formula ROH are distilled off and an alkali metal methoxyethoxide of the general formula M.sup.+[MeOEtO.sup.] is obtained in the bottom of the column.

A process for the depletion of 2-methoxyethanol (MOE) from a mixture comprising predominantly morpholine (MO) (crude morpholine), wherein crude morpholine is distilled in a distillation column in the presence of an alkali metal compound of the general formula M.sup.+[RO.sup.] (M.sup.+ is alkali metal cation and R is hydrogen (H), methyl, ethyl, propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl), where MO and a compound of the general formula ROH are distilled off and an alkali metal methoxyethoxide of the general formula M.sup.+[MeOEtO.sup.] is obtained in the bottom of the column.

The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl or alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.

The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl or alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.

Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions.

Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions.

The invention relates to a method for preparing a compound (I) or one of the salts thereof, and the uses of said method, R.sup.1OOCC(X)CHR.sup.2R.sup.3(I), wherein X is selected among O; NR, wherein R is H or a C1-C6 alkyl; and NOR wherein R is H, or a C1-C6 alkyl or an alkylaryl; R.sup.1 is H or a C1-C6 alkyl group; R.sup.2 is H, a C1-C6 alkyl, or an alkylaryl; and R.sup.3 is CH.sub.2SR.sup.4 or CH.sub.2SeR.sup.4, where R.sup.4 is H or a C1-C6 alkyl from a compound (II), or one of the salts thereof, R.sup.1OOCC(X)CHR.sup.2R.sup.5 and R.sup.5 is H or COOR.sup.6, where R.sup.6 is H or a C1-C6 alkyl, said method being carried out in the presence of a compound (III) CH.sub.2(Y)(Z). Wherein Y is H; OR.sup.7, where R.sup.7 is H, a C1-C6 alkyl or an acyl with formula COR.sup.4; SR.sup.4 or SeR.sup.4 where R.sup.4 matches the preceding definition; or 1 NR.sup.8R.sup.9, where R.sup.8 and R.sup.9, identical or different, each or together are a C1-C6 alkyl, or an alkylaryl; Z, identical or different to Y, is OR.sup.10 where R.sup.10 is H, a C1-C6 alkyl or COR.sup.4; a cyclic or acyclic N(COR.sup.4)(COR.sup.4) group; or NR.sup.11R.sup.12, where R.sup.11 and R.sup.12, identical or different, each or together are a C1-C6 alkyl or an alkylaryl; wherein Y and Z together are O; said method involving an intermediate product (IV) R.sup.1OOCC(X)CHR.sup.2CH.sub.2Z.

The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.