The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure

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Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

A dry sprinkler includes a flexible tube section that maintains a pressurized fluid, such as a liquid antifreeze solution, between a first end and a second end. A first seal prevents fluid from a supply line from entering the flexible tube section. The first seal is maintained in a sealed position by a pressure of the pressurized fluid. A sprinkler head is coupled to the second end of the flexible tube section, and includes a frame, an output orifice, a deflector, a second seal that seals the output orifice, and a thermally responsive element configured to maintain the second seal in a sealed position when the thermally responsive element is in a non-responsive state. A differential pressure controller maintains a ratio between the pressure of the pressurized fluid in the flexible tube section and a pressure of a supply fluid in the supply line to at least a certain ratio.

The present invention provides an epoxy compound indicated by chemical formula (1) (in chemical formula (1), X indicates a C1-10 aliphatic hydrocarbon group, R.sub.1 and R.sub.2 each independently indicate one selected from the group consisting of a hydrogen atom, an aliphatic hydrocarbon group, an aromatic group, an alkoxy group, and a halogen atom.)

##STR00001##

The present invention provides an epoxy compound indicated by chemical formula (1) (in chemical formula (1), X indicates a C1-10 aliphatic hydrocarbon group, R.sub.1 and R.sub.2 each independently indicate one selected from the group consisting of a hydrogen atom, an aliphatic hydrocarbon group, an aromatic group, an alkoxy group, and a halogen atom.)

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The present invention relates to the use of hydrophilic compounds of the formula I as photopolymerisation initiators of polymerisable substance mixtures which comprise unsaturated compounds, or for the photochemical crosslinking of linear polymers, ##STR00001##
in which the parameters have the meaning indicated in Claim 1, to sealants for liquid-crystal displays which comprise the hydrophilic photoinitiators, to novel hydrophilic photoinitiators of the formula I, and to the liquid-crystal displays produced using these sealants.

The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.

The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.

The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): ##STR00001##
Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.

The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): ##STR00001##
wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.

The present invention relates to the use of hydrophilic compounds of the formula I as photopolymerisation initiators of polymerisable substance mixtures which comprise unsaturated compounds, or for the photochemical crosslinking of linear polymers,

##STR00001##

in which the parameters have the meaning indicated in Claim 1, to sealants for liquid-crystal displays which comprise the hydrophilic photoinitiators, to novel hydrophilic photoinitiators of the formula I, and to the liquid-crystal displays produced using these sealants.