The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection. ##STR00001##

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Disclosed are compounds of formulae:

##STR00001##

and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16, R.sub.17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Processes for conversion of propylene polyol feed into useful petrochemical products, including olefin monomers, are described. Such processes comprise: adding a feed stream comprising one or more propylene polyols to a dehydration cleavage reaction zone in the presence of a dehydration cleavage catalyst and reacting at a pressure and temperature sufficient to form a product stream comprising propionaldehyde, a dioxolane component, and a dioxane component; and adding the product stream and hydrogen to a dehydration reaction zone in the presence of a hydrogenation catalyst to form and reacting at a pressure and temperature sufficient to form a second product stream comprising a propanol component. The second product can be added to a dehydration reaction zone in the presence of a dehydration catalyst and reacted at a pressure and temperature sufficient to form a third product stream comprising propylene.

To provide a compound highly active against pests, a pesticide using the compound, and a method for controlling pests by applying the compound. A phenoxyalkylbenzamide compound represented by the formula (I) or its salt; a pesticide containing it as an active ingredient, and a controlling method, which comprises applying an effective amount of the compound: ##STR00001##
wherein R.sup.1, Y and R.sup.3 are a hydrogen atom or the like, and Ar is as follows: ##STR00002##
wherein R.sup.4 and R.sup.7 are halogen or the like, R.sup.5 and R.sup.6 are a hydrogen atom or the like, m is from 0 to 5, and n is from 0 to 3.

To provide a compound highly active against pests, a pesticide using the compound, and a method for controlling pests by applying the compound. A phenoxyalkylbenzamide compound represented by the formula (I) or its salt; a pesticide containing it as an active ingredient, and a controlling method, which comprises applying an effective amount of the compound: ##STR00001##
wherein R.sup.1, Y and R.sup.3 are a hydrogen atom or the like, and Ar is as follows: ##STR00002##
wherein R.sup.4 and R.sup.7 are halogen or the like, R.sup.5 and R.sup.6 are a hydrogen atom or the like, m is from 0 to 5, and n is from 0 to 3.

Provided herein are compounds of formula I: ##STR00001##
and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.

Provided herein are compounds of formula I: ##STR00001##
and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.

Described herein is a cyclic fluorinated compound of formula (I) where: L is O, CH.sub.2, or a covalent bond; X is selected from F or CF.sub.3, and Y is selected from H, F, or CF.sub.3, wherein when X is CF.sub.3 then Y is F and when Y is CF.sub.3 then X is F, each R.sub.f.sup.1 is independently selected from a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; or the two R.sub.f.sup.1 groups are bonded together to form a fluorinated ring structure comprising 4-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; the CFZCHAQ group is bonded to a ring carbon that is alpha to at least one O atom of the ring; A is selected from F, or CF.sub.3; Z is selected from H, F, or CF.sub.3; and Q is selected from (i) a F atom, (ii) a Cl atom, (iii) a linear, cyclic, or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof, or (iv) a G(R.sub.f.sup.2).sub.e group, where G is an O atom or a N atom wherein: when Q is a Cl atom, then Z and A are F atoms; when G is O then e is 1, Z is H, F, or CF.sub.3; A is F; and R.sub.f.sup.2 is a linear or branched perfluorinated alkyl group comprising 1-10 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; when G is N then e is 2, and each R.sub.f.sup.2 group is independently a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof or the two R.sub.f.sup.2 groups are bonded together to form a fluorinated ring structure comprising 4-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof, with the proviso that when A is CF.sub.3 then Z is F, and when Z is CF.sub.3 then A is F. ##STR00001##

Described herein is a cyclic fluorinated compound of formula (I) where: L is O, CH.sub.2, or a covalent bond; X is selected from F or CF.sub.3, and Y is selected from H, F, or CF.sub.3, wherein when X is CF.sub.3 then Y is F and when Y is CF.sub.3 then X is F, each R.sub.f.sup.1 is independently selected from a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; or the two R.sub.f.sup.1 groups are bonded together to form a fluorinated ring structure comprising 4-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; the CFZCHAQ group is bonded to a ring carbon that is alpha to at least one O atom of the ring; A is selected from F, or CF.sub.3; Z is selected from H, F, or CF.sub.3; and Q is selected from (i) a F atom, (ii) a Cl atom, (iii) a linear, cyclic, or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof, or (iv) a G(R.sub.f.sup.2).sub.e group, where G is an O atom or a N atom wherein: when Q is a Cl atom, then Z and A are F atoms; when G is O then e is 1, Z is H, F, or CF.sub.3; A is F; and R.sub.f.sup.2 is a linear or branched perfluorinated alkyl group comprising 1-10 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof; when G is N then e is 2, and each R.sub.f.sup.2 group is independently a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof or the two R.sub.f.sup.2 groups are bonded together to form a fluorinated ring structure comprising 4-8 carbon atoms and optionally comprising at least one catenated atom selected from O, N, or combinations thereof, with the proviso that when A is CF.sub.3 then Z is F, and when Z is CF.sub.3 then A is F. ##STR00001##