A recycling method of polylactic acid in a single step by using supercritical or dense gas carbon dioxide is provided. The recycling method includes the steps of adjusting a temperature of a reactor to at least 120° C., and adjusting a pressure to values above or below a critical pressure of carbon dioxide, wherein the critical pressure is 73.8 bar.

A recycling method of polylactic acid in a single step by using supercritical or dense gas carbon dioxide is provided. The recycling method includes the steps of adjusting a temperature of a reactor to at least 120° C., and adjusting a pressure to values above or below a critical pressure of carbon dioxide, wherein the critical pressure is 73.8 bar.

The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.

The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.

Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

The invention discloses a method for the preparation of fluoro alkylated 1,4-dioxene by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides of 1,4-dioxane in the presence of a base.

The invention discloses a method for the preparation of fluoro alkylated 1,4-dioxene by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides of 1,4-dioxane in the presence of a base.

A process for the manufacture of ethyleneamines and ethanolamines, comprising the steps of (i) converting a glycolaldehyde derivative of formula (II), in which R.sup.2, R.sup.3 are—the same or different—hydrogen, alkyl, such as C.sub.1-6-alkyl, or cycloalkyl such as Cs-e-cycloalkyl; and an animating agent of formula (III); in which R1 is hydrogen (H), alkyl, such as C.sub.1-6-alkyl, or cycloalkyl such as C.sub.3-6-cycloalkyl, in the gas or liquid phase; (ii) feeding the reaction products obtained in step (i) into a hydrogenation reactor, where the reaction products are converted with hydrogen in the presence of a hydrogenation catalyst.

##STR00001##

An electrolyte includes diglycolic anhydride and a trinitrile compound, with which the cycle performance and the high-temperature stability under over-discharge conditions of lithium-ion batteries are significantly improved. The electrolyte includes a compound of Formula I; and at least one of a compound of Formula II or a compound of Formula III;

##STR00001##

R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen, halo, substituted or unsubstituted C.sub.1-C.sub.10 alkyl, substituted or unsubstituted C.sub.2-C.sub.10 alkenyl, substituted or unsubstituted C.sub.2-C.sub.10 alkynyl, substituted or unsubstituted C.sub.6-C.sub.12 aryl, substituted or unsubstituted C.sub.1-C.sub.10 alkoxy, or substituted or unsubstituted C.sub.6-C.sub.12 aryloxy, wherein when substituted, the substituent is halo, cyano, or C.sub.1-C.sub.10 alkyl; and a, d and f are each independently selected from an integer from 1 to 5, and b, c, e, g, h and i are each independently selected from an integer from 0 to 5.

An electrolyte includes diglycolic anhydride and a trinitrile compound, with which the cycle performance and the high-temperature stability under over-discharge conditions of lithium-ion batteries are significantly improved. The electrolyte includes a compound of Formula I; and at least one of a compound of Formula II or a compound of Formula III;

##STR00001##

R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen, halo, substituted or unsubstituted C.sub.1-C.sub.10 alkyl, substituted or unsubstituted C.sub.2-C.sub.10 alkenyl, substituted or unsubstituted C.sub.2-C.sub.10 alkynyl, substituted or unsubstituted C.sub.6-C.sub.12 aryl, substituted or unsubstituted C.sub.1-C.sub.10 alkoxy, or substituted or unsubstituted C.sub.6-C.sub.12 aryloxy, wherein when substituted, the substituent is halo, cyano, or C.sub.1-C.sub.10 alkyl; and a, d and f are each independently selected from an integer from 1 to 5, and b, c, e, g, h and i are each independently selected from an integer from 0 to 5.