Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof (Formula (1)) wherein K, Z, R.sup.2, R.sup.3 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxides and salts, processes for making such compounds, N-oxides, salts and compositions, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound, N-oxide, salt or composition. ##STR00001##

Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof (Formula (1)) wherein K, Z, R.sup.2, R.sup.3 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds, N-oxides and salts, processes for making such compounds, N-oxides, salts and compositions, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound, N-oxide, salt or composition. ##STR00001##

Disclosed are compounds of Formulae 1 and 10 including all geometric and stereoisomers, tautomers, N oxides, and salts thereof, wherein E, L, J, A, T, R1, R2a, R2b, X, Y, R6a, R6b and R29 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

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Process for the preparation of a compound with at least one five-membered cyclic monothiocarbonate group wherein a) a compound with at least one epoxy group is used as starting material b) the compound is reacted with phosgene or an alkyl chloroformate thus giving an adduct and c) the adduct is reacted with a compound comprising anionic sulfurthus obtaining the compound with at least one five-membered cyclic monothiocarbonate group.

Process for the preparation of a compound with at least one five-membered cyclic monothiocarbonate group wherein a) a compound with at least one epoxy group is used as starting material b) the compound is reacted with phosgene or an alkyl chloroformate thus giving an adduct and c) the adduct is reacted with a compound comprising anionic sulfurthus obtaining the compound with at least one five-membered cyclic monothiocarbonate group.

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.

The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (I-A):

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wherein R1 and R2 represent independently a hydrogen atom or a deuterium atom; A represents an oxygen or nitrogen atom; and SERM-F represents a selective estrogen receptor modulator fragment comprising an aryl or heteroaryl group linked to the adjacent “A” group.

The invention also relates to the preparation and to the therapeutic uses of the compounds of formula (I-A) as inhibitors and degraders of estrogen receptors.

The present invention provides the compounds having the general formula: (I) wherein R.sup.1 to R.sup.8, and X are as described herein, compositions including the compounds and methods of using the compounds.

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The present invention provides the compounds having the general formula: (I) wherein R.sup.1 to R.sup.8, and X are as described herein, compositions including the compounds and methods of using the compounds.

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