A compound of formula (I) is:

##STR00001##

wherein: X.sup.2 represents a —CO—NR.sub.k— group, a —NR′.sub.k—CO— group, a —O— group, a —CO— group, a —SO.sub.2-group, a —CS—NH— group, a —CH.sub.2—NH—, a

##STR00002##

group, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y.sup.2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C.sub.1-C.sub.4)alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a (C.sub.5-C.sub.11)bicycloalkyl group, an adamantyl group, a piperidinyl group, a (C.sub.1-C.sub.4)alkenyl group, a —PO(OR.sub.a)(OR.sub.b) group, a 5-membered heteroaromatic ring or a —CR.sup.1R.sup.2R.sup.3 group, or any of its pharmaceutically acceptable salt.

The invention relates to a method of separation by fractionalization of the antioxidant active ingredients of Rosemary plant, which are the diterpenes Carnosic acid and Camosol and the phenolic acid Rosmarinic Acid, through column chromatography method. The production process involves the passage of rosemary extract, which is obtained in/with a proper solvent, through a column packed with a suitable packing material, the separation of the part rich in carnosic acid and carnosol, and the obtainment of a deodorized product in powder form after drying. During the process, another extract containing rosmarinic acid with high antioxidant activity is also obtained. The invention thus allows the use of an extract rich in carnosic acid and carnosol and another extract containing rosmarinic acid—which are obtained at once with no need for additional processes like acidification, precipitation, membrane filtration or deodorization—in food, pharmaceutical and cosmetic sector applications.

Provided are a stereoisomer of an epoxy compound that when contained in a curable composition, can improve the heat resistance and dielectric properties of the cured product of the curable composition, a curable composition containing the stereoisomer, and a cured product of the curable composition. A stereoisomer of an epoxy compound represented by Formula (1) below, the stereoisomer being represented by Formula (2), and a curable composition containing the stereoisomer are used:

##STR00001##

in which in Formula (1), R.sup.1 to R.sup.18 are each independently selected from the group consisting of hydrogen, an alkyl group, and an alkoxy group; and

##STR00002##

in which in Formula (2), R.sup.1 to R.sup.18 are each the same as in Formula (1).

Provided are a stereoisomer of an epoxy compound that when contained in a curable composition, can improve the heat resistance and dielectric properties of the cured product of the curable composition, a curable composition containing the stereoisomer, and a cured product of the curable composition. A stereoisomer of an epoxy compound represented by Formula (1) below, the stereoisomer being represented by Formula (2), and a curable composition containing the stereoisomer are used:

##STR00001##

in which in Formula (1), R.sup.1 to R.sup.18 are each independently selected from the group consisting of hydrogen, an alkyl group, and an alkoxy group; and

##STR00002##

in which in Formula (2), R.sup.1 to R.sup.18 are each the same as in Formula (1).

The present disclosure relates, in part, to certain compounds comprising brusatol derivatives, or a pharmaceutically acceptable salt, solvate, or polymorph thereof, which are useful for the treatment of hematological malignancies, including but not limited to leukemia and lymphoma. In certain embodiments, the present disclosure relates to pharmaceutical compositions of the compounds of the present disclosure.

The present disclosure relates, in part, to certain compounds comprising brusatol derivatives, or a pharmaceutically acceptable salt, solvate, or polymorph thereof, which are useful for the treatment of hematological malignancies, including but not limited to leukemia and lymphoma. In certain embodiments, the present disclosure relates to pharmaceutical compositions of the compounds of the present disclosure.

The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.

One or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof are provided for use in the treatment and/or prevention of a metabolic disorder in a feline animal, preferably where the metabolic disorder is one or more selected from the group consisting of ketoacidosis, pre-diabetes, diabetes mellitus type 1 or type 2, insulin resistance, obesity, hyperglycemia, impaired glucose tolerance, hyperinsulinemia, dyslipidemia, dysadipokinemia, subclinical inflammation, systemic inflammation, low grade systemic inflammation, hepatic lipidosis, atherosclerosis, inflammation of the pancreas, neuropathy and/or Syndrome X (metabolic syndrome) and/or loss of pancreatic beta cell function and/or where the remission of the metabolic disorder, preferably diabetic remission, is achieved and/or maintained.