Patent classifications
C07D495/16
Inhibitors of Bruton's tyrosine kinase and methods of their use
The present disclosure is directed to compounds of Formula (I) and methods of their use and preparation, as well as compositions comprising compounds of Formula (I). ##STR00001##
HETEROCYCLIC COMPOUND
One of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity. Another of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity and exhibits a protein degradation induction activity. The present invention provides a compound represented by formula (I) (the symbols in the formula are as defined in the present Description) and salts thereof.
##STR00001##
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
Provided are a novel compound capable of improving the luminous efficiency, stability and lifespan of an element, an organic electronic element using the same, and an electronic device thereof.
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
Provided are a novel compound capable of improving the luminous efficiency, stability and lifespan of an element, an organic electronic element using the same, and an electronic device thereof.
ORGANIC COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE AND ELECTRONIC APPARATUS THEREOF
The present application relates to an organic compound, and there are electron transport and injection groups and a conjugated fused heteroaromatic ring in a structure of the organic compound. The organic compound can be used in a functional layer of an organic light-emitting device (OLED). When used in an OLED, the organic compound of the present application can improve the light-emitting efficiency and service life of the OLED.
Heterocyclic compound
One of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity. Another of the purposes of the present invention is to provide a heterocyclic derivative that has an IAP (particularly XIAP) binding (inhibiting) activity and exhibits a protein degradation induction activity. The present invention provides a compound represented by formula (I) (the symbols in the formula are as defined in the present Description) and salts thereof. ##STR00001##
HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
- Wilfried Braje ,
- George Doherty ,
- Katja Jantos ,
- Cheng Ji ,
- Andrew Judd ,
- Aaron Kunzer ,
- Anthony Mastracchio ,
- Xiaohong Song ,
- Andrew Souers ,
- Gerard Sullivan ,
- Zhi-Fu Tao ,
- Chunqiu Lai ,
- Jesse Teske ,
- Michael Wendt ,
- Patrick Brady ,
- Xilu Wang ,
- Thomas Penning ,
- Yujia Dai ,
- Jane Gong ,
- Roberto Risi ,
- Yiyun Yu ,
- Guidong ZHU
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
- Wilfried Braje ,
- George Doherty ,
- Katja Jantos ,
- Cheng Ji ,
- Andrew Judd ,
- Aaron Kunzer ,
- Anthony Mastracchio ,
- Xiaohong Song ,
- Andrew Souers ,
- Gerard Sullivan ,
- Zhi-Fu Tao ,
- Chunqiu Lai ,
- Jesse Teske ,
- Michael Wendt ,
- Patrick Brady ,
- Xilu Wang ,
- Thomas Penning ,
- Yujia Dai ,
- Jane Gong ,
- Roberto Risi ,
- Yiyun Yu ,
- Guidong ZHU
The present disclosure provides for compounds of Formula (I)
##STR00001##
wherein A.sup.2, A.sup.3, A.sup.4, A.sup.6, A.sup.7, A.sup.8, A.sup.15, R.sup.A, R.sup.5, R.sup.9, R.sup.10A, R.sup.10B, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).