The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

The present invention relates to seco (opened ring) macrolide compounds, to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, to macrolide based macrocycles obtained from said seco macrolide compounds, to the process for preparation of macrolide based macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to the use of macrolide based macrocycles as therapeutic agents.

The present invention relates to compounds of Formula I, methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

##STR00001##

The present disclosure relates to redox active materials, such as the compound of formula (I), comprising at least one 2,5-dithio-7-azabicyclo(2.2.1)heptane unit connected to a surface thereof, as well as processes for making said redox active materials. The present disclosure relates to a method for recovering a metal, comprising reacting a metal in oxidized state with said redox active material. The present disclosure relates to uses of these redox active materials in sensors, electronic materials and for extracting metals. ##STR00001##

The present disclosure relates to redox active materials, such as the compound of formula (I), comprising at least one 2,5-dithio-7-azabicyclo(2.2.1)heptane unit connected to a surface thereof, as well as processes for making said redox active materials. The present disclosure relates to a method for recovering a metal, comprising reacting a metal in oxidized state with said redox active material. The present disclosure relates to uses of these redox active materials in sensors, electronic materials and for extracting metals. ##STR00001##

Novel compounds having D3 receptor antagonistic activity are provided.

A compound represented by formula (I):

##STR00001##

wherein
ring A is a heterocycle, X.sup.1 is each independently CR.sup.4aR.sup.4b, X.sup.2 is each independently CR.sup.4cR.sup.4d, Y.sup.1 and Y.sup.2 are each independently a carbon atom or a nitrogen atom,
L is N(R.sup.6)C(O) or the like, W is cyclyl or the like, R.sup.2 and R.sup.3 are each independently substituted or unsubstituted alkyl or the like, R.sup.1a, R.sup.1b, R.sup.4a to R.sup.4d, and R.sup.6 are each independently hydrogen atoms or the like,
p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.

Novel compounds having D3 receptor antagonistic activity are provided.

A compound represented by formula (I):

##STR00001##

wherein
ring A is a heterocycle, X.sup.1 is each independently CR.sup.4aR.sup.4b, X.sup.2 is each independently CR.sup.4cR.sup.4d, Y.sup.1 and Y.sup.2 are each independently a carbon atom or a nitrogen atom,
L is N(R.sup.6)C(O) or the like, W is cyclyl or the like, R.sup.2 and R.sup.3 are each independently substituted or unsubstituted alkyl or the like, R.sup.1a, R.sup.1b, R.sup.4a to R.sup.4d, and R.sup.6 are each independently hydrogen atoms or the like,
p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.

Pateamine A derivatives, pharmaceutical compositions that include the derivatives, and methods for treating chronic lymphocytic leukemia using the derivatives.

Pateamine A derivatives, pharmaceutical compositions that include the derivatives, and methods for treating chronic lymphocytic leukemia using the derivatives.

Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are -amino pateamine A derivatives that lack the C5-methyl group of pateamine A.