The present invention pertains to a process for producing three-dimensional, self-supporting and/or substrate-supported formed pieces or structures on surfaces by means of site-selective solidification of a liquid to pasty, organic or organically modified material within a bath consisting of this material by means of two- or multiphoton polymerization, whereby the material has at least one compound that has both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group, and/or wherein the bath material additionally contains groups or radicals, which are available for an inorganic crosslinking or which are already inorganically crosslinked, providing that both an organic radical polymerizable via two-photon or multiphoton polymerization and a biocompatible, biodegradable or bioresorbable group must be contained in the material. The formed pieces or surface structures according to the present invention are suitable as matrices for binding live cells, which can be multiplied after that or stimulated for the production of specific substances. They can be used, e.g., as an extracorporeal matrix or as an implant.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Compound of the general formula (Ia), (Ib) and (Ic) R.sub.50 and R.sub.60 are different form each other and are selected from the group consisting of R.sub.70, ZR.sub.70, ZOH, ZNH.sub.2, ZSH, ZOC(O)R.sub.70, OC(O)R.sub.70, COOH and its corresponding salts, C(O)NH.sub.2, C(O)NHR.sub.70, C(O)N(R.sub.70).sub.2, COOR.sub.70, ZCOOH and its corresponding salts, ZC(O)NHR.sub.70, ZC(O)NH.sub.2, ZC(O)N(R.sub.70).sub.2, ZCOOR.sub.70, CH(COOH).sub.2 and its corresponding salts, CH(COOR.sub.70).sub.2, and ZSO.sub.3 wherein R.sub.70 is selected from the group consisting of a linear or branched C.sub.1 to C.sub.20 alkyl, (C.sub.1 to C.sub.10)-alkyloxy-(C.sub.1 to C.sub.10)-alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.6 to C.sub.12 aryl, C.sub.3 to C.sub.10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C.sub.1 to C.sub.10 alkyl, linear or branched C.sub.3 to C.sub.10 cycloalkyl, a linear or branched C.sub.6 to C.sub.10 aryl or a (C.sub.1 to C.sub.10)-alkyloxy-(C.sub.1 to C.sub.10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

##STR00001##

Compound of the general formula (Ia), (Ib) and (Ic) R.sub.50 and R.sub.60 are different form each other and are selected from the group consisting of R.sub.70, ZR.sub.70, ZOH, ZNH.sub.2, ZSH, ZOC(O)R.sub.70, OC(O)R.sub.70, COOH and its corresponding salts, C(O)NH.sub.2, C(O)NHR.sub.70, C(O)N(R.sub.70).sub.2, COOR.sub.70, ZCOOH and its corresponding salts, ZC(O)NHR.sub.70, ZC(O)NH.sub.2, ZC(O)N(R.sub.70).sub.2, ZCOOR.sub.70, CH(COOH).sub.2 and its corresponding salts, CH(COOR.sub.70).sub.2, and ZSO.sub.3 wherein R.sub.70 is selected from the group consisting of a linear or branched C.sub.1 to C.sub.20 alkyl, (C.sub.1 to C.sub.10)-alkyloxy-(C.sub.1 to C.sub.10)-alkyl, C.sub.2 to C.sub.10 alkenyl, C.sub.6 to C.sub.12 aryl, C.sub.3 to C.sub.10 cycloalkyl, cycloalkylalkyl and cycloalkylalkenyl, wherein Z is a linear or branched C.sub.1 to C.sub.10 alkyl, linear or branched C.sub.3 to C.sub.10 cycloalkyl, a linear or branched C.sub.6 to C.sub.10 aryl or a (C.sub.1 to C.sub.10)-alkyloxy-(C.sub.1 to C.sub.10)-alkyl, cycloalkylalkyl and cycloalkylalkenyl.

##STR00001##

Disclosed herein is a method to selectively acylate a polyol, the method comprising the steps of: (a) providing a mixture comprising a polyol, an acylation agent, a N-heterocyclic carbene (NHC) precursor, a base and a solvent; and (b) subjecting the mixture to an elevated temperature for a period of time to provide a selectively acylated polyol, optionally wherein the mixture further comprises boronic acid.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.